Document Detail


Vancomycin dosing chart for use in patients with renal impairment.
MedLine Citation:
PMID:  3337096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new vancomycin dosing chart for use in patients with impaired renal function is described. The chart has been adapted from a previously published nomogram, based on a linear relationship between vancomycin clearance and creatinine clearance. Doses are designed to achieve an average steady-state serum concentration of approximately 15 mg/L. Use of the chart necessitates first measuring or estimating the patient's body weight and creatinine clearance. The chart provides the advantages of generating an exact dose and dosing interval, as well as being somewhat easier to use than the original nomogram. Predicted average steady-state serum concentrations resulting from the dosing chart range from 12.1 to 18.2 mg/L, with a mean of 15.0 mg/L.
Authors:
D L Brown; L S Mauro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  11     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-24     Completed Date:  1988-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacy Services, Medical College Hospitals, Medical College of Ohio, Toledo.
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MeSH Terms
Descriptor/Qualifier:
Body Weight
Glomerular Filtration Rate
Humans
Kidney / metabolism
Kidney Failure, Chronic*
Kidney Function Tests
Vancomycin / administration & dosage*,  pharmacokinetics
Chemical
Reg. No./Substance:
1404-90-6/Vancomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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