| Vanadium derivatives act as growth factor--mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells. | |
| | |
MedLine Citation:
|
PMID: 7675039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of different vanadium compounds on proliferation and differentiation was examined in osteoblast-like UMR106 cells. Vanadate increased the cell growth in a biphasic manner, the higher doses inhibiting cell progression. Vanadyl stimulated cell proliferation in a dose-responsive manner. Similar to vanadate, pervanadate increased osteoblast-like cell proliferation in a biphasic manner but no inhibition of growth was observed. Vanadyl and pervanadate were stronger stimulators of cell growth than vanadate. Only vanadate was able to regulate the cell differentiation as measured by cell alkaline phosphatase activity. These results suggest that vanadium derivatives behave like growth factors on osteoblast-like cells and are potential pharmacological tools in the control of cell growth. |
| | |
Authors:
|
A M Cortizo; S B Etcheverry |
Related Documents
:
|
6368369 - Growth of preadipocyte cell lines and cell strains from rodents in serum-free hormone-s... 11811789 - Oncostatin m and leukemia inhibitory factor regulate the growth of normal human breast ... 1417799 - Production of a low molecular weight growth inhibitory factor by adenovirus 12-transfor... 8110499 - Acute effects of growth factors on t-47d breast cancer cell cycle progression. 9671979 - Generation and characterization of embryonic striatal conditionally immortalized st14a ... 10362639 - Cell type-specific requirement of the mapk pathway for the growth factor action of gast... 21552939 - A role for histamine in human-malignant glioma-cells. 18757369 - Blockade of the rhoa-jnk-c-jun-mmp2 cascade by atorvastatin reduces osteosarcoma cell i... 22028619 - Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal c... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Molecular and cellular biochemistry Volume: 145 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 1995 Apr |
Date Detail:
|
Created Date: 1995-10-19 Completed Date: 1995-10-19 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 97-102 Citation Subset: IM |
Affiliation:
|
Cátedra de Bioquimica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Differentiation / drug effects Cell Division / drug effects Growth Substances / pharmacology* Osteoblasts / drug effects* Rats Stimulation, Chemical Tumor Cells, Cultured Vanadium / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Growth Substances; 7440-62-2/Vanadium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mammalian-heart adenylate deaminase: cross-species immunoanalysis of tissue distribution with a card...
Next Document: Interleukin 1 activation of the AP-1 transcription complex in murine T cells is regulated at the lev...