Document Detail

Vanadium derivatives act as growth factor--mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells.
MedLine Citation:
PMID:  7675039     Owner:  NLM     Status:  MEDLINE    
The effect of different vanadium compounds on proliferation and differentiation was examined in osteoblast-like UMR106 cells. Vanadate increased the cell growth in a biphasic manner, the higher doses inhibiting cell progression. Vanadyl stimulated cell proliferation in a dose-responsive manner. Similar to vanadate, pervanadate increased osteoblast-like cell proliferation in a biphasic manner but no inhibition of growth was observed. Vanadyl and pervanadate were stronger stimulators of cell growth than vanadate. Only vanadate was able to regulate the cell differentiation as measured by cell alkaline phosphatase activity. These results suggest that vanadium derivatives behave like growth factors on osteoblast-like cells and are potential pharmacological tools in the control of cell growth.
A M Cortizo; S B Etcheverry
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  145     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
Cátedra de Bioquimica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina.
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MeSH Terms
Cell Differentiation / drug effects
Cell Division / drug effects
Growth Substances / pharmacology*
Osteoblasts / drug effects*
Stimulation, Chemical
Tumor Cells, Cultured
Vanadium / pharmacology*
Reg. No./Substance:
0/Growth Substances; 7440-62-2/Vanadium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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