Document Detail

Valvular regurgitation impact on left ventricular 2-dimensional and Doppler echocardiographic indices in patients with essential hypertension.
MedLine Citation:
PMID:  21053709     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Blacks have both a higher hypertension prevalence and accelerated cardiac end organ damage. Because blacks also have a higher prevalence of valvular heart disease, which occurs at a younger age than for whites, we further examined the contribution of valvular regurgitation to the severity of hypertensive heart disease in Nigerians.
METHODS: We evaluated and compared echocardiographic indexes in 75 essential hypertensive Nigerians with (n=48) and without (n=27) valvular regurgitations. Demographic and echocardiographic indices, as well as the types and severity of valvular lesions were compared between the groups using bivariate logistic regression and analysis of variance.
RESULTS: The 2 groups were of similar demographics, but those with regurgitations had larger cardiac size (p < .05), greater mass (147 +/- 31 vs. 122 +/- 32 g/m2, p = .01) higher volume (p < .01), and left atrial size (35.6 +/- 4.6 vs. 33.3 +/- 4.6 mm, p < .05). Atrial size, cardiac volume, and dimension were independent correlates/predictors of regurgitation occurrence. Relative wall thickness of at least 0.6 was more common in regurgitation patients. Cardiac mass was correlated to increasing age (r = 0.23, p = .043). The valvular lesions frequencies were aortic regurgitation, 8; mitral regurgitation, 22; and mixed, 18. The aortic orifice dimension was significantly different among the regurgitant cases, highest in aortic regurgitation (p = .001). Aortic orifice dimension increased with hypertension duration (p = .028).
CONCLUSIONS: Regurgitant lesions are common and occur early in hypertensive Africans. Apparently mild valvular regurgitation may accentuate preclinical concentric hypertrophy in hypertensive blacks.
Olufemi E Ajayi; T Collete Abiona; Michael O Balogun; Adesuyi A Leslie Ajayi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  102     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2010-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  937-42     Citation Subset:  IM    
Division of Cardiology, Department of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria.
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MeSH Terms
African Continental Ancestry Group / statistics & numerical data
Echocardiography, Doppler*
Heart Valve Diseases / epidemiology*
Heart Ventricles / pathology,  ultrasonography
Hypertension / epidemiology*,  ultrasonography*
Hypertrophy, Left Ventricular / ultrasonography
Middle Aged
Organ Size
Ventricular Function, Left

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