| Valvular dysfunction and venous obstruction in the post-thrombotic syndrome. | |
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MedLine Citation:
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PMID: 19303507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medical thrombosis physicians have tended to view deep vein thrombosis (DVT) as essentially a problem of biology and hematology. This "field condition" concept holds that in susceptible individuals, DVT risk factors lead to a global hypercoagulable state which results in venous thrombosis. However, less attention has been paid to the key problems of venous anatomy and physiology that lead to the post-thrombotic syndrome (PTS) and its major health consequences. The primary objectives of this article are: (1) to review the macroscopic pathophysiology of PTS; (2) to discuss the roles of valvular reflux and venous obstruction in the development of PTS; and (3) to explore new endovascular PTS prevention and treatment strategies that feature the prevention or elimination of valvular reflux and late venous obstruction to improve DVT patient outcomes. |
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Authors:
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Suresh Vedantham |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Thrombosis research Volume: 123 Suppl 4 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-03-23 Completed Date: 2009-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: S62-5 Citation Subset: IM |
Affiliation:
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Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. vedanthams@mir.wustl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticoagulants / therapeutic use Balloon Dilatation Combined Modality Therapy Fibrinolytic Agents / therapeutic use Humans Laser Therapy Postthrombotic Syndrome / pathology, physiopathology*, prevention & control, therapy Recurrence Thrombectomy Thrombolytic Therapy Treatment Outcome Venous Thrombosis / pathology, physiopathology*, therapy Venous Valves / pathology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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