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The Values of CA-125, Progesterone, ß-HCG and Estradiol in the Early Prediction of Ectopic Pregnancy.
MedLine Citation:
PMID:  22496937     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To explore the diagnostic value and measurement of serum CA-125, the single measurement of progesterone (P), ß-HCG, and estradiol (E2) in the early diagnosis of ectopic pregnancy.
METHODS: Serum levels of CA-125, progesterone, ß-HCG and estradiol were measured by Enzyme Linked Immuno Sorbent Assay (ELISA) techniques in 40 symptomatic women with ectopic pregnancy and 24 women with normal intrauterine pregnancy during gestational age of 4-10 weeks at Al-Kadhmiya Teaching Hospital, Baghdad, Iraq, between November 2010 and June 2011.
RESULTS: The mean ±SEM serum levels of CA-125, progesterone, ß-HCG, and estradiol in patients with ectopic pregnancies (16.51±2.39U/ml; 2.54±0.47ng/ml; 72.75±12.27mIU/ml; 13.4±2.14pg/ml; respectively) were significantly lower than the levels in normal intrauterine pregnancies (74.25±18.5U/ml; 28.36±3.7ng/ml; 249.54±18.0mIU/ml; 112.7±23.6pg/ml; respectively). When using a CA-125 concentration of 20.5 U/ml as a cut-off value for the diagnosis of ectopic pregnancy, sensitivity was 75.7%, specificity 100%, the positive predictive value was 100% and the negative predictive value 71.4%.
CONCLUSION: The measurement of CA-125 and progesterone levels is useful in discriminating ectopic from normal gestations.
Authors:
Meena M Abdul-Hussein; Omar F Abdul-Rasheed; Hala Abdul Qadir Al-Moayed
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oman medical journal     Volume:  27     ISSN:  2070-5204     ISO Abbreviation:  Oman Med J     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-12     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101526350     Medline TA:  Oman Med J     Country:  Oman    
Other Details:
Languages:  eng     Pagination:  124-8     Citation Subset:  -    
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