Document Detail

Value of virtual touch tissue quantification in stages of diabetic kidney disease.
MedLine Citation:
PMID:  24764333     Owner:  NLM     Status:  In-Data-Review    
Objectives- The purpose of this study was to evaluate Virtual Touch tissue quantification (VTQ; Siemens AG, Erlangen, Germany) in stages of diabetic kidney disease. Methods- A total of 120 patients with type 2 diabetes mellitus were divided into 3 groups according to their urinary albumin-to-creatinine ratio (ACR): normoalbuminuria (ACR <30 mg/g of creatinine), microalbuminuria (ACR 30-300 mg/g), and macroalbuminuria (ACR ≥300 mg/g and estimated glomerular filtration rate ≥30 mL/min/1.73 m(2)). Thirty volunteers served as controls. Virtual Touch tissue quantification was performed in the 4 groups to determine the shear wave velocity (SWV) of the renal cortex, and changes in the SWV were compared between the groups. Correlation analysis was performed between the SWV and ACR in the type 2 diabetes groups. Results- When SWVs were compared, there was no significant difference between the normoalbuminuria and control group (P = .40), but there was a significant difference between the microalbuminuria and macroalbuminuria groups and the control group (P < .05). There was also a significant difference between each pair of type 2 diabetes groups (P < .05). The correlation coefficient for the SWV and log(ACR) in type 2 diabetes was 0.773 (P < .05). Receiver operating characteristic curve analysis showed that the area under the curve for SWV diagnosis of diabetes complicated by renal injury was 0.93; the best cutoff point, sensitivity, and specificity were 2.43 m/s, 85.7%, and 84.5%, respectively. Conclusions- It is feasible to use VTQ to determine the renal cortical SWV for judging renal injury in type 2 diabetes mellitus. The SWV increases as the renal injury progresses and thus plays an important role in diabetic kidney disease stages.
Ning Yu; Yueyue Zhang; Yan Xu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  33     ISSN:  1550-9613     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  787-92     Citation Subset:  IM    
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