| Value of tissue Doppler echocardiography in predicting response to cardiac resynchronization therapy in patients with heart failure. | |
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MedLine Citation:
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PMID: 20381669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several studies have demonstrated a relation between left ventricular (LV) dyssynchrony and response to cardiac resynchronization therapy (CRT). Many methods of determining LV dyssynchrony have been proposed, including a value of 65 ms as assessed by tissue Doppler imaging. The aim of the present validation study was to prospectively test the predictive accuracy of the 65-ms cutoff for LV dyssynchrony in a large cohort of patients with heart failure undergoing CRT. The study included 361 patients who had undergone CRT. The clinical and echocardiographic parameters were assessed at baseline and at 6 months of follow-up. The clinical response was defined as an improvement of > or = 1 New York Heart Association class, and the echocardiographic response was defined as a reduction in LV end-systolic volume of > or = 15%. At 6 months of follow-up, 259 patients (72%) had a clinical response and 187 patients (52%) had an echocardiographic response. The patients with a response had more LV dyssynchrony than did those without a response (91 + or - 49 ms vs 50 + or - 44 ms for the clinical response and 101 + or - 46 ms vs 55 + or - 45 ms for the echocardiographic response). On multivariate analysis, LV dyssynchrony remained predictive of the response, independent of other characteristics. In conclusion, LV dyssynchrony of > or = 65 ms was an independent predictor of both the clinical and the echocardiographic response in patients with heart failure who underwent CRT in this validation study. |
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Authors:
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Rutger J Van Bommel; Claudia Ypenburg; C Jan Willem Borleffs; Victoria Delgado; Nina Ajmone Marsan; Matteo Bertini; Eduard R Holman; Martin J Schalij; Jeroen J Bax |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-20 |
Journal Detail:
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Title: The American journal of cardiology Volume: 105 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-06-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1153-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Volume Defibrillators, Implantable Echocardiography, Doppler, Color / methods* Electric Countershock / methods* Female Follow-Up Studies Heart Failure / physiopathology, therapy*, ultrasonography Heart Ventricles / physiopathology, ultrasonography* Humans Male Predictive Value of Tests Prospective Studies Reproducibility of Results Severity of Illness Index Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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