| Value of thyroid stimulating antibody in the diagnosis of thyroid associated ophthalmopathy of euthyroid patients. | |
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MedLine Citation:
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PMID: 9497469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS/BACKGROUND: Thyroid associated ophthalmopathy (TAO) of euthyroid patients is difficult to diagnose because clinical findings overlap with other conditions, and no confirmatory diagnostic tests are available. Recently, it was reported that TSH binding inhibitor immunoglobulin (TBII) and thyroid stimulating antibody (TSAb) are sensitive markers of TAO. The sensitivity of these antibodies in the detection of TAO were therefore studied to determine if they could be a useful criterion in the diagnosis of TAO of euthyroid patients. METHODS: Serum values of TBII and TSAb of 35 patients with euthyroid TAO (group A) were compared with those of 27 patients with Graves' disease and TAO (group B). The relation between the serum value of TSAb and the eye symptoms of patients with euthyroid TAO were also examined by multiple linear regression analysis. RESULTS: In group A, TBII was positive in 10 cases (28.6%) and TSAb was positive in 29 cases (82.9%). In group B, both TBII and TSAb were positive in all cases (100%). The titre of serum TBII in group A (15.6% (SD 18.0%)) was significantly lower (p < 0.0001) than in group B (57.9% (21.5%)). The titre of serum TSAb in group A (1400.9% (2163.9%)) was significantly lower (p = 0.0026) than in group B (2243.9% (1472.8%)). Among the eye findings of patients with euthyroid TAO, keratopathy was significantly (p = 0.034) related to the value of TSAb. CONCLUSION: These results suggest that the activity of TSAb is a more sensitive marker of euthyroid TAO than is TBII, and could be a useful criterion in the diagnosis of TAO of euthyroid patients. |
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Authors:
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K Kazuo; T Fujikado; G Ohmi; J Hosohata; Y Tano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 81 ISSN: 0007-1161 ISO Abbreviation: Br J Ophthalmol Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-03-16 Completed Date: 1998-03-16 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1080-3 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Osaka University Medical School, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Autoantibodies / blood Biological Markers / blood Female Follow-Up Studies Graves Disease / diagnosis*, physiopathology Humans Immunoglobulins, Thyroid-Stimulating / blood* Male Middle Aged Receptors, Thyrotropin / blood Thyroid Gland / physiopathology Thyrotropin / blood Thyroxine / blood Triiodothyronine / blood |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Biological Markers; 0/Immunoglobulins, Thyroid-Stimulating; 0/Receptors, Thyrotropin; 0/thyrotropin-binding inhibitory immunoglobulin; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
| Comments/Corrections | |
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