| Value of technetium-99m diethyltriamine pentaaceticacid radioaerosol inhalation lung scintigraphy for the stage of amiodarone-induced pulmonary toxicity. | |
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MedLine Citation:
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PMID: 15193819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Amiodarone is a potent antiarrhythmic agent that is limited in clinical use by its adverse effects, including potentially life threatening amiodarone-induced pulmonary toxicity (AIPT). The alteration of technetium-99m diethyltriaminepentaaceticacid (Tc-99m DTPA) radioaerosol lung clearance in AIPT was experimentally investigated. METHODS: Eighteen white New Zealand rabbits (initial weight 4.1+/-0.2 kg) were divided into two groups. AIPT group (n=13) was administered amiodarone (20 mg/kg BW) ip as a 5% aqueous solution for 6 week. The controls (n=5) were administered the same amount of 0.9% saline ip. Four rabbits of AIPT group died due to AIPT. The reminders of AIPT group (n=9) and controls underwent Tc-99m DTPA radioaerosol lung scintigraphy at the end of the treatment period. AIPT group was divided into two subgroups according to histopathologic evaluation. AIPT-I had interstitial pneumonitis (n=4) and AIPT-II had interstitial pneumonitis with fibrosis (n=5). RESULTS: The mean T(1/2) values of in control, AIPT-I, and AIPT-II groups were found 54+/-4.4, 39.2+/-11.7 and 114.6+/-16.7 min, respectively. The mean T(1/2) values of Tc-99m DTPA significantly differ than other groups (X(2)=11.78, P=0.02). The significantly increased T(1/2) values was noted in AIPT-II group when compared with control (P=0.001). In contrast, AIPT-I group has significantly lower T(1/2) values than control group (P=0.03). CONCLUSION: We suggested that Tc-99m DTPA radioaerosol inhalation lung scintigraphy provides an accurate evaluation about stage of lung toxicity and therefore may be a useful tool for the monitoring of AIPT. |
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Authors:
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Gulay Durmus-Altun; Armagan Altun; Yavuz Sami Salihoglu; Semsi Altaner; Sakir Berkada; Gulay Ozbay |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cardiology Volume: 95 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-06-14 Completed Date: 2004-09-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 193-7 Citation Subset: IM |
Affiliation:
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Nuclear Medicine Department, Edirne, Turkey. altun@medscape.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Amiodarone / adverse effects* Analysis of Variance Animals Anti-Arrhythmia Agents / adverse effects* Diagnosis, Differential Drug Monitoring Lung Diseases, Interstitial / chemically induced*, radionuclide imaging* Pulmonary Fibrosis / chemically induced*, radionuclide imaging* Rabbits Radiopharmaceuticals / diagnostic use* Sensitivity and Specificity Technetium Tc 99m Pentetate / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Anti-Arrhythmia Agents; 0/Radiopharmaceuticals; 1951-25-3/Amiodarone; 65454-61-7/Technetium Tc 99m Pentetate |
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