Document Detail

Value of sperm characteristics and the result of in-vitro fertilization for predicting the outcome of assisted reproduction.
MedLine Citation:
PMID:  2312189     Owner:  NLM     Status:  MEDLINE    
The outcome of procedures for assisted reproduction, namely in-vitro fertilization (IVF) and gamete intrafallopian transfer (GIFT) were used as end-points to assess the capacity of particular sperm characteristics to predict the fertilizing potential of semen. In addition, the result of IVF performed with spare oocytes from the GIFT procedure, was used to predict the pregnancy outcome of GIFT. The power of sperm characteristics to predict the outcome of assisted reproduction procedures was poor. With regard to the outcome of IVF, sperm morphology was the best discriminant. The threshold value of 16% normal sperm morphology could be used as a good predictor of successful IVF, but could not be applied as a criterion to reject an IVF trial. For the latter purpose, the limit of 5% sperm with normal morphology should be used. The proportion of sperm with grade A motility in native semen provided the best discrimination between GIFT-fertile and GIFT-infertile cases. A negative result from IVF performed with spare oocytes was 93% accurate in predicting unsuccessful outcome of GIFT. Hence, diagnostic IVF is the most sensitive assay for male fertility. The occurrence of oocyte fertilization during IVF predicts a successful outcome of GIFT in only 50% of cases. Hence, a negative result in IVF indicates that semen is almost certainly infertile, but a positive result does not guarantee the successful outcome of GIFT.
A Hinting; F Comhaire; L Vermeulen; M Dhont; A Vermeulen; D Vandekerckhove
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of andrology     Volume:  13     ISSN:  0105-6263     ISO Abbreviation:  Int. J. Androl.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8000141     Medline TA:  Int J Androl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Department of Internal Medicine, State University Hospital, Ghent, Belgium.
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MeSH Terms
Fertilization in Vitro*
Gamete Intrafallopian Transfer
Predictive Value of Tests
Sperm Count*
Sperm Motility / physiology*
Spermatozoa / cytology*

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