| Value of single oral loading dose of propafenone in converting recent-onset atrial fibrillation. Results of a randomized, double-blind, controlled study. | |
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MedLine Citation:
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PMID: 9347277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate the efficacy and safety of a single loading oral dose of propafenone in the interruption of recent-onset atrial fibrillation. METHODS: After a complete medical history, physical examination, 12-lead ECG, chest X-ray, and routine biochemical laboratory testing, 55 consecutive patients with recent-onset atrial fibrillation were randomized double-blind in the emergency department for the administration of either a single oral dose (450 to 750 mg) of propafenone (29 cases) or a placebo (26 cases). After the 24-h observation period, comprehensive echocardiographic examination was performed. RESULTS: The groups were homogeneous as regards biological, clinical and echocardiographic characteristics. Two hours after treatment, 12 patients (41%) on propafenone but only two (8%) on placebo had converted to sinus rhythm (P = 0.005). This striking difference was maintained 6 h after treatment (65 vs 31%; P = 0.015) but lessened at 12 h (69% vs 42%; P = 0.060) and was insignificant at the end of the 24-h treatment period (79%, vs 73%; P = 0.752). Apart from hypotension, transient in three cases and sustained in one whose later echocardiographic examination demonstrated left systolic ventricular dysfunction, propafenone was well tolerated. CONCLUSION: Although there is no significant difference in the rates of conversion 24 h after treatment, propafenone works faster than placebo in achieving sinus rhythm. This rapid action of oral propafenone can be useful to solve quickly the clinical problems of a high proportion of patients arriving at the emergency department with acute atrial fibrillation. |
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Authors:
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J Azpitarte; M Alvarez; O Baún; R García; E Moreno; F Martín; L Tercedor; R Fernández |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European heart journal Volume: 18 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-11-24 Completed Date: 1997-11-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1649-54 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Hospital Universitario Virgen de las Nieves, Granada, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Oral Anti-Arrhythmia Agents / administration & dosage*, adverse effects, therapeutic use Atrial Fibrillation / drug therapy*, physiopathology Dose-Response Relationship, Drug Double-Blind Method Electrocardiography Female Humans Male Middle Aged Propafenone / administration & dosage*, adverse effects, therapeutic use Prospective Studies Safety Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 54063-53-5/Propafenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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