Document Detail


Value of serum and synovial fluid activin A and inhibin A in some rheumatic diseases.
MedLine Citation:
PMID:  20704626     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The purpose of the study is to measure serum and synovial fluid levels of activin A and inhibin A in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and osteoarthritis (OA) and correlate them with disease activity parameters.
SUBJECTS AND METHODS: This study included 60 patients with various rheumatic diseases (20 with RA, 20 with SLE and 20 with OA), as well as 10 healthy controls. All of them were subjected to complete history-taking, examination and estimation of disease activity index. The following investigations were done for all subjects: serum and synovial activin A, inhibin A, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-dsDNA and complements 3 and 4.
RESULTS: Serum levels of activin A were significantly higher in RA, SLE and OA than controls and in RA and SLE versus OA The mean values of serum inhibin A were significantly higher in all studied groups than controls. Synovial activin A and inhibin A were significantly higher in RA than OA. Positive correlations were found between serum activin A and disease activity parameters of RA. In SLE, positive correlations were found between serum activin A and inhibin A with ESR and SLE Disease Activity Index.
CONCLUSIONS: Serum activin A and inhibin A were significantly higher in RA and SLE. Serum levels correlated positively with disease activity parameters of RA and SLE. However, synovial levels were significantly higher in RA than OA but showed no correlation or negative correlation with disease activity. We recommend further studies to detect the exact role of activin A and inhibin A in these conditions.
Authors:
Salwa S El-Gendi; Alaa E A Moniem; Nabawia M Tawfik; Mohammed M Ashmawy; Omnia A Mohammed; Ahmed K Mostafa; Madiha M Zakhari; Omar M Herdan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of rheumatic diseases     Volume:  13     ISSN:  1756-185X     ISO Abbreviation:  Int J Rheum Dis     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-13     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474930     Medline TA:  Int J Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
Affiliation:
Departments of Internal Medicine, Assiut University Hospital, Assiut, Egypt. salwaelgendi@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Antinuclear / blood
Arthritis, Rheumatoid / blood,  immunology,  metabolism*
Biological Markers / blood,  metabolism
Blood Sedimentation
C-Reactive Protein / metabolism
Complement C3 / metabolism
Complement C4 / metabolism
DNA / immunology
Egypt
Female
Humans
Inhibin-beta Subunits / blood,  metabolism*
Inhibins / blood,  metabolism*
Lupus Erythematosus, Systemic / blood,  immunology,  metabolism*
Male
Middle Aged
Osteoarthritis, Knee / blood,  immunology,  metabolism*
Severity of Illness Index
Synovial Fluid / metabolism*
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Biological Markers; 0/Complement C3; 0/Complement C4; 0/inhibin beta A subunit; 0/inhibin-alpha subunit; 57285-09-3/Inhibins; 9007-41-4/C-Reactive Protein; 9007-49-2/DNA; 93443-12-0/Inhibin-beta Subunits

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