Document Detail


Value of serum ferritin and soluble transferrin receptor for prediction of coronary artery disease and its clinical presentations.
MedLine Citation:
PMID:  15135258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated whether there is an association between serum ferritin or soluble transferrin receptor (sTfR) concentrations and coronary artery disease (CAD) or its clinical presentations. This is a case-control study that included 892 patients (664 cases with angiographically proven CAD and 228 controls without CAD). Blood was collected before angiography for determination of sTfR, ferritin and C-reactive protein (CRP). The values (median, 25th-75th percentiles) of sTfR (2.6 [2.1; 3.2]mg/l versus 2.4 [2.1; 3.0]mg/l, P = 0.13) or ferritin (140.1 [74.8; 248.3]ng/ml versus 120.1 [74.9; 218.0]ng/ml, P = 0.11) did not differ significantly between cases or controls. The values of sTfR in the case subjects with 1-vessel, 2-vessel, and 3-vessel CAD were: 2.4 [2.0; 3.0], 2.6 [2.0; 3.2], and 2.8 [2.2; 3.3]mg/l, respectively (P = 0.003). In multivariate analysis, neither sTfR (chi2 = 0.14, P = 0.70) nor ferritin (chi2 = 2.8, P = 0.09) correlated independently with the presence of CAD. In case subjects with stable angina, unstable angina, and acute myocardial infarction (MI), ferritin concentrations were: 127.5 [69.5; 214.0], 138.9 [86.1; 278.0], and 175.0 [93.5; 314.5]ng/ml, respectively (P < 0.001). Our results showed that serum concentrations of sTfR or ferritin do not predict the risk for coronary artery disease. In subjects with pre-existing CAD, those with more severe disease had increased levels of sTfR. Patients with CAD presenting with acute coronary syndromes showed increased levels of serum ferritin.
Authors:
Siegmund Braun; Gjin Ndrepepa; Nicolas von Beckerath; Wolfgang Vogt; Albert Schömig; Adnan Kastrati
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  174     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-11     Completed Date:  2004-10-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
Affiliation:
Institut für Laboratoriumsmedizin, Deutsches Herzzentrum München, Technische Universität, Lazarettstrasse 36, 80636 München, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Case-Control Studies
Coronary Angiography
Coronary Artery Disease / blood*,  radiography*
Female
Ferritins / blood*,  metabolism
Humans
Male
Middle Aged
Predictive Value of Tests
Probability
Receptors, Transferrin / blood*,  metabolism
Reference Values
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Solubility
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Transferrin; 9007-73-2/Ferritins

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