Document Detail

Value of serum C-reactive protein measurement in the detection of hepatocellular carcinoma superimposed on liver cirrhosis.
MedLine Citation:
PMID:  7507117     Owner:  NLM     Status:  MEDLINE    
We investigated whether, in Italian patients, C-reactive protein (CRP) determination could be considered a useful adjunct, complementary to alpha 1-fetoprotein, in the detection of liver cancer. CRP was determined by particle-enhanced nephelometry in 171 subjects (102 male, 69 female). Fifty-five patients had mild chronic liver disease (CLD), 45 cirrhosis (CIR), 38 hepatocellular carcinoma (HCC); 33 subjects were healthy controls. Patients with HCC and CIR had higher CRP levels (P < 0.05) than those found in patients with CLD and controls. CRP higher than 5 mg/l was found in 30/38 (78.9%) patients with HCC, 28/45 (62.2%) patients with CIR, 16/55 (29.1%) patients with CLD (chi 2 56.0, P < 0.0001). Sensitivity, specificity and diagnostic accuracy of CRP in diagnosing HCC with respect to CLD+CIR were: 78.9%, 56.0% and 34.9%. However, when considered only in the subgroup of patients with alpha 1-fetoprotein below or equalling 30 ng/ml, they were 50.0%, 54.3% and 4.3% respectively. In conclusion, CRP concentration is frequently elevated in patients with HCC, however, it does not seem to improve the ability of alpha 1-fetoprotein to discriminate HCC from CIR.
C Fabris; M Pirisi; G Soardo; E Falleti; F Pezzetta; D Vitulli; P Toniutto; N Bortolotti; F Gonano; E Bartoli
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  120     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-02-22     Completed Date:  1994-02-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  229-32     Citation Subset:  IM    
Cattedra di Medicina Interna, Università degli Studi di Udine, Italy.
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MeSH Terms
Aged, 80 and over
C-Reactive Protein / analysis*
Carcinoma, Hepatocellular / blood,  complications*,  diagnosis*
Diagnosis, Differential
Liver Cirrhosis / blood*,  complications*
Liver Neoplasms / blood,  complications*,  diagnosis*
Middle Aged
Predictive Value of Tests
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/alpha-Fetoproteins; 9007-41-4/C-Reactive Protein

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