| Value of multiparametric prostate MRI of the peripheral zone. | |
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MedLine Citation:
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PMID: 21247742 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: MRI of the prostate offers the possibility to localize and stage prostate cancer and may improve detection of disease. Currently, T2-weighted images and spectroscopy are the most commonly used MRI techniques. To assess the value of prostate MRI and its different modalities in the process of diagnosis, the currently available MRI techniques were compared. MATERIALS AND METHODS: 16 patients were examined on a 1.5 T MR system. All patients underwent the same MR protocol using an endorectal coil: T2-weighted triplanar turbo-spin-echo (TSE), axial echo-planar diffusion-weighted imaging (DWI), 3D chemical-shift imaging MR spectroscopy (MRS) and axial dynamic-contrast-enhanced TurboFLASH (DCE). Parametric maps of the choline+creatine/citrate ratio (CC-CR), apparent diffusion coefficient (ADC) and plasma flow/mean transit time (PF/MTT) were calculated. Additionally, average time for reading and scanning were evaluated. As reference, biopsy results were used. RESULTS: Sensitivity/specificity were 50.0-85.7%/44.4-72.2% for the T2 weighted images, 78.6-100.0%/38.9-55.6% for the ADC maps, 71.4-85.7%/44.4-55.6% for the PF/MTT maps and 64.3-78.6%/50.0-77.8% for the CC-CR. Average scan and reading time were 8:46/1:54min for T2, 1:28/3:17min for DWI, 8:41/2:12min for DCE and 11:36/3:47 for spectroscopy. CONCLUSION: We found no significant differences in accuracy between the modalities. We observed DWI to be advantageous in examination and reading compared to DCE and MRS, therefore it might be the preferred modality when a shortened protocol is needed. |
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Authors:
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Anja M Weidner; Henrik J Michaely; Andreas Lemke; Lutz Breitinger; Frederik Wenz; Alexander Marx; Stefan O Schoenberg; Dietmar J Dinter |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-17 |
Journal Detail:
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Title: Zeitschrift fur medizinische Physik Volume: - ISSN: 0939-3889 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886455 Medline TA: Z Med Phys Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010. Published by Elsevier GmbH. |
Affiliation:
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Department of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Mannheim, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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