Document Detail

Value of morning home blood pressure as a predictor of decline in renal function in patients with chronic kidney disease.
MedLine Citation:
PMID:  18635925     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although blood pressure (BP) control is significantly associated with progression of chronic kidney disease (CKD), the influence of BP control based on home BP (HBP) measurement on the change in renal function in CKD patients is not fully defined. METHODS: We recruited 137 patients with stage 3-5 CKD, who performed daily HBP measurements continuously. HBP was measured every morning and evening and data were obtained every 6 months in each patient with a follow-up of 32 +/- 5 months. The associations between BP data, other clinical variables and the change in estimated glomerular filtration rate (eGFR) were examined. RESULTS: Mean morning BP, evening BP and clinic BP were 132.9/76.2, 128.5/72.5 and 129.4/69.1 mm Hg, respectively. There were significant correlations between mean morning systolic BP (SBP), mean evening SBP, mean clinic SBP and the change in eGFR (r = -0.318, -0.215, -0.174, p < 0.0001, <0.05, <0.05). Stepwise multivariate regression analysis demonstrated mean morning SBP and mean urinary protein excretion as independent predictors of the change in eGFR. CONCLUSION: Morning SBP is a more significant predictor of decline in renal function than evening SBP or clinic SBP.
Tomonari Okada; Toshiyuki Nakao; Hiroshi Matsumoto; Yume Nagaoka
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Publication Detail:
Type:  Journal Article     Date:  2008-07-17
Journal Detail:
Title:  American journal of nephrology     Volume:  28     ISSN:  1421-9670     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-08     Completed Date:  2008-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  982-9     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Department of Nephrology, Tokyo Medical University, Tokyo, Japan.
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MeSH Terms
Antihypertensive Agents / pharmacology
Blood Pressure / drug effects,  physiology
Blood Pressure Determination / methods*
Glomerular Filtration Rate
Kidney / physiopathology*
Kidney Failure, Chronic / diagnosis,  physiopathology*
Middle Aged
Regression Analysis
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents

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