Document Detail

Value of maternal serum alpha-fetoprotein levels of 5.0 MOM or greater and prenatal sonography in predicting fetal outcome.
MedLine Citation:
PMID:  7690492     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine fetal outcomes and the capability of sonography to help predict these outcomes in patients with maternal serum alpha-fetoprotein (MSAFP) levels of 5.0 multiples of the median or greater. MATERIALS AND METHODS: Real-time sonography was performed in patients with singleton and multiple gestations. After sonography, the pregnancy was monitored. RESULTS: Inaccurate historical dating caused elevated MSAFP levels in 14 patients. In the remaining 72 singleton gestations, 42 fetuses (58%) had anomalies, 13 (18%) died in utero or after birth, three (4%) had intrauterine growth retardation or were premature, and 14 (19%) were normal, with no complications. A poor outcome occurred in 58 (80%) of the singleton pregnancies, and sonography depicted an abnormality in 49 (84%) of these patients. CONCLUSION: Most pregnant patients with MSAFP levels of 5.0 MOM or greater have an unfavorable outcome. Sonography depicts most of these abnormal pregnancies.
J M Larson; D H Pretorius; N E Budorick; A L Scioscia
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  189     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-10-14     Completed Date:  1993-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  AIM; IM    
Department of Radiology, University of California, San Diego Medical Center.
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MeSH Terms
Abdominal Muscles / abnormalities
Abnormalities, Multiple / diagnosis,  ultrasonography
Chromosome Aberrations / diagnosis,  ultrasonography
Chromosome Disorders
Fetal Death
Fetal Diseases / diagnosis*,  ultrasonography*
Fetal Monitoring
Gestational Age
Neural Tube Defects / diagnosis,  ultrasonography
Placenta Diseases / diagnosis,  ultrasonography
Pregnancy Complications / diagnosis,  ultrasonography
Pregnancy Outcome*
Pregnancy, Multiple
Ultrasonography, Prenatal*
alpha-Fetoproteins / analysis*
Reg. No./Substance:

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