Document Detail

Value of maternal fructosamine in the screening of an unselected population for hyperglycemia-related complications in the newborn.
MedLine Citation:
PMID:  8155209     Owner:  NLM     Status:  MEDLINE    
The relationship between the maternal serum fructosamine concentration and pregnancy outcome was studied in 765 consecutive subjects of an obstetric community hospital population. The neonatal outcome of patients with a fructosamine concentration in pregnancy below and above 2.30 mmol/L were compared. Patients with a fructosamine concentration above 2.30 mmol/L did not show an increased incidence of neonatal hypoglycemia, hyperbilirubinemia, or respiratory distress syndrome. On the other hand, they did give birth to infants with a higher birthweight ratio, a variable defined as newborn weight corrected for sex, gestational age, and parity. However, the predictive value with respect to birthweight ratio was modest: Fructosamine accounted for only 1.4% of the variation in birthweight ratio, much less than other well-known contributors to this variation, such as smoking (10%) and prepregnancy maternal (6.5%) or paternal weight (2.8%). The screening value of fructosamine to identify patients who would give birth to a macrosomic infant was limited irrespective the gestational age at measurement. It is concluded that fructosamine determined during pregnancy in an unselected obstetric population is an unsuitable screening method to trace patients with an increased risk to deliver of an infant with neonatal complications of maternal hyperglycemia.
T H Salemans; M P van Dieijen-Visser; P J Brombacher; L L Peeters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  11     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, De Wever and Gregorius Hospital, Heerlen/Brunssum, The Netherlands.
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MeSH Terms
Birth Weight
Diabetes, Gestational / blood*,  epidemiology
Hexosamines / blood*
Hyperglycemia / blood*,  epidemiology
Hypoglycemia / epidemiology*
Infant, Newborn
Jaundice, Neonatal / epidemiology*
Mass Screening / methods
Pregnancy / blood*
Pregnancy Outcome / epidemiology
Respiratory Distress Syndrome, Newborn / epidemiology*
Risk Factors
Reg. No./Substance:
0/Hexosamines; 4429-04-3/Fructosamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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