Document Detail


Value of intraoperative EEG changes during corpus callosotomy in predicting surgical results.
MedLine Citation:
PMID:  8422865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intraoperative transformation of generalized epileptiform discharges (GED) to lateralized epileptiform activity during the course of corpus callosum sectioning for intractable epilepsy in 37 patients was correlated with percentage of decrease in atonic-tonic seizures with "drops" at mean follow-up of 26 months (range 12-86 months). Twenty-seven (73%) patients had intraoperative interictal discharges, and 21 (78%) showed varying degrees of lateralization of GED during corpus callosum sectioning (two thirds to total). All patients experienced > 80% reduction in atonic-tonic seizures with drops. The group (n = 7) with largest decrease in GED had the greatest decrease in seizures (95.5%). Six patients without change in GED had 88% decrease in seizures, as did 14 patients (85-86%) with mild or moderate decreases in GED, but there was no statistically significant correlation between decrease in GED and seizure frequency after operation. Thus, although lateralization of GED after corpus callosum sectioning was evident in 78% of patients with GED, the degree of lateralization of GED did not correlate with degree of reduction of tonic-atonic seizures. Therefore, intraoperative surface EEG monitoring does not appear to be helpful at this time as a guide to extent of callosotomy.
Authors:
M E Fiol; J R Gates; R Mireles; R E Maxwell; D M Erickson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epilepsia     Volume:  34     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:    1993 Jan-Feb
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  74-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Minnesota, Minneapolis.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Brain / physiopathology
Child
Child, Preschool
Corpus Callosum / surgery*
Electroencephalography*
Epilepsy, Generalized / diagnosis,  physiopathology*,  surgery
Female
Functional Laterality / physiology*
Humans
Male
Middle Aged
Monitoring, Intraoperative*
Prognosis
Grant Support
ID/Acronym/Agency:
P50 NS16308/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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