| Value of intraoperative EEG changes during corpus callosotomy in predicting surgical results. | |
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MedLine Citation:
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PMID: 8422865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intraoperative transformation of generalized epileptiform discharges (GED) to lateralized epileptiform activity during the course of corpus callosum sectioning for intractable epilepsy in 37 patients was correlated with percentage of decrease in atonic-tonic seizures with "drops" at mean follow-up of 26 months (range 12-86 months). Twenty-seven (73%) patients had intraoperative interictal discharges, and 21 (78%) showed varying degrees of lateralization of GED during corpus callosum sectioning (two thirds to total). All patients experienced > 80% reduction in atonic-tonic seizures with drops. The group (n = 7) with largest decrease in GED had the greatest decrease in seizures (95.5%). Six patients without change in GED had 88% decrease in seizures, as did 14 patients (85-86%) with mild or moderate decreases in GED, but there was no statistically significant correlation between decrease in GED and seizure frequency after operation. Thus, although lateralization of GED after corpus callosum sectioning was evident in 78% of patients with GED, the degree of lateralization of GED did not correlate with degree of reduction of tonic-atonic seizures. Therefore, intraoperative surface EEG monitoring does not appear to be helpful at this time as a guide to extent of callosotomy. |
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Authors:
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M E Fiol; J R Gates; R Mireles; R E Maxwell; D M Erickson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Epilepsia Volume: 34 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 1993 Jan-Feb |
Date Detail:
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Created Date: 1993-02-25 Completed Date: 1993-02-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 74-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Minnesota, Minneapolis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain / physiopathology Child Child, Preschool Corpus Callosum / surgery* Electroencephalography* Epilepsy, Generalized / diagnosis, physiopathology*, surgery Female Functional Laterality / physiology* Humans Male Middle Aged Monitoring, Intraoperative* Prognosis |
| Grant Support | |
ID/Acronym/Agency:
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P50 NS16308/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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