| Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome. | |
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MedLine Citation:
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PMID: 15308434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine whether the initial chest radiograph is helpful in predicting the clinical outcome of patients with severe acute respiratory syndrome (SARS). METHODS: Of 343 patients who met the World Health Organization's case definition of probable SARS and who had been admitted to a regional hospital in Hong Kong, 201 patients had laboratory evidence of SARS coronavirus infection. The initial frontal chest radiographs of these 201 patients were assessed in a blinded fashion by 3 radiologists; individual findings were accepted if at least 2 of the radiologists concurred. Independent predictors of an adverse outcome, defined as the need for assisted ventilation, death, or both, were identified by multivariate analysis. RESULTS: Bilateral disease and involvement of more than two zones on the initial chest radiograph were associated with a higher risk of liver impairment and poor clinical outcome. Forty-two patients (21%) developed an adverse outcome. Multivariate analysis showed that lung involvement of more than two zones (odds ratio [OR] = 7.0; 95% confidence interval [CI]: 2.7 to 17.9), older age (OR for each decade of life = 1.5; 95% CI: 1.1 to 2.0), and shortness of breath on admission (OR = 2.8; 95% CI: 1.1 to 7.4) were independent predictors of an adverse outcome. CONCLUSION: Frontal chest radiographs on presentation may have prognostic value in patients with SARS. |
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Authors:
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Tai-Nin Chau; Po-Oi Lee; Kin-Wing Choi; Chiu-Man Lee; Ka-Fai Ma; Tak-Yin Tsang; Yuk-Keung Tso; Ming-Chee Chiu; Wing-Lok Tong; Wai-Cho Yu; Sik-To Lai |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 117 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-13 Completed Date: 2004-09-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: United States |
Other Details:
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Languages: eng Pagination: 249-54 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine and Geriatrics, Princess Margaret Hospital, Lai Chi Kok, Hong Kong Special Administrative Region. chautainin@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / metabolism Biological Markers / blood Female Hong Kong / epidemiology Humans Lung / pathology, radiography, virology Male Middle Aged Multivariate Analysis Observer Variation Patient Admission Predictive Value of Tests ROC Curve Radiographic Image Enhancement Radiography, Thoracic* / standards* Respiration, Artificial Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Risk Factors SARS Virus Serologic Tests Severe Acute Respiratory Syndrome / diagnosis*, epidemiology, therapy Statistics as Topic Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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