Document Detail

Value of immunohistochemistry in the diagnosis of leukemia cutis: study of 54 cases using paraffin-section markers.
MedLine Citation:
PMID:  1383298     Owner:  NLM     Status:  MEDLINE    
A grave prognosis is usually associated with leukemic skin infiltrates (leukemia cutis). However, some leukemic skin infiltrates are clinically similar to reactive non-leukemic infiltrates in patients with leukemia; thus it is of great importance to distinguish them. Fifty-four cases which were thought clinically to be leukemia cutis underwent immunophenotyping with a panel of nine T, B, monocytic, and macrophage markers using paraffin sections. Immunohistochemistry helped identify 44 cases with leukemia cutis and 10 with reactive infiltrates. In all cases of leukemia cutis, the staining patterns of skin infiltrates were concordant with cell type in the bone marrow. Furthermore, the panel of markers was usually helpful in distinguishing reactive from leukemia infiltrates, especially in cases with chronic lymphatic leukemia. Immunohistochemistry is a valuable adjunct in histopathologic differentiation of skin infiltrates in most cases of leukemia. With formalin-fixed, paraffin-embedded biopsies, we recommend that CD45 (LCA), CD45RO (UCHL-1), CD3, CD20 (L-26), CD43 (Leu-22), CD68 (KP-1), lysozyme, and chloroacetate esterase be considered in cases of systemic leukemia with cutaneous papules and nodules that prove difficult to interpret with routine section.
K V Ratnam; W P Su; S C Ziesmer; C Y Li
Related Documents :
11042518 - Outcome of clonal hemophagocytic lymphohistiocytosis: analysis of 32 cases.
8426468 - Cytogenetic heterogeneity in t(11;19) acute leukemia: clinical, hematological and cytog...
3461608 - Ovarian granulocytic sarcoma with central nervous system involvement.
8616078 - Molecular detection of t(8;21)/aml1-eto in aml m1/m2: correlation with cytogenetics, mo...
19585368 - Combined intravitreal bevacizumab and triamcinolone acetonide injection for idiopathic ...
9894968 - Analysis of dural configuration for evaluation of posterior decompression in cervical m...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  19     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-11-03     Completed Date:  1992-11-03     Revised Date:  2011-09-07    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  193-200     Citation Subset:  IM    
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Antigens, CD / analysis
Antigens, CD20
Antigens, CD3 / analysis
Antigens, CD43
Antigens, CD45 / analysis
Antigens, Differentiation, B-Lymphocyte / analysis
Antigens, Differentiation, Myelomonocytic / analysis
Bone Marrow / enzymology,  immunology,  pathology
Cell Movement
Dermatitis / diagnosis,  immunology,  pathology
Immunohistochemistry / standards*
Leukemia / diagnosis*,  immunology,  pathology
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis,  immunology,  pathology
Leukemic Infiltration / diagnosis*,  immunology,  pathology
Lymphocytes, Tumor-Infiltrating / enzymology,  immunology,  pathology
Macrophages / enzymology,  immunology,  pathology
Middle Aged
Muramidase / analysis
Sialoglycoproteins / analysis
Skin / chemistry,  immunology,  pathology
Staining and Labeling
Tumor Markers, Biological / analysis,  immunology
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD20; 0/Antigens, CD3; 0/Antigens, CD43; 0/Antigens, Differentiation, B-Lymphocyte; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 0/Sialoglycoproteins; 0/Tumor Markers, Biological; 0/UN1 sialoglycoprotein, human; 8002-74-2/Paraffin; EC, CD45; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Epidermal Langerhans cells after allogeneic bone marrow transplantation: depletion by chemotherapy c...
Next Document:  Harlequin fetus with abnormal lamellar granules and giant mitochondria.