Document Detail


Value of exercise thallium-201 imaging in patients with diagnostic and nondiagnostic exercise electrocardiograms.
MedLine Citation:
PMID:  7270433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of exercise imaging with thallium-201 in the evaluation of patients suspected of having coronary artery disease was studied in 194 patients undergoing diagnostic coronary arteriography. Ninety-eight patients had 70 percent or more narrowing of one or more coronary vessels and 96 patients had either no or insignificant coronary artery disease. One hundren twenty-three of the 194 patients had conclusive treadmill exercise electrocardiograms (either positive or negative), and 71 had inconclusive exercise electrocardiograms. Fifty-four of the 98 patients with coronary artery disease were receiving propranolol at the time of testing. Forty-five (83 percent) of the 54 patients receiving propranolol and 33 (75 percent) of the 44 patients not receiving propranolol had abnormal exercise thallium images (difference not significant). In patients with conclusive exercise electrocardiograms the sensitivity of exercise imaging was not significantly different from that of exercise electrocardiograms (80 versus 74 percent), but the sensitivity of both tests combined (92 percent) was higher than that of either test alone (p less than 0.01). The specificity of exercise imaging (97 percent) electrocardiograms the sensitivity of exercise imaging was not significantly different from that of exercise electrocardiograms (80 versus 74 percent), but the sensitivity of both tests combined (92 percent) was higher than that of either test alone (p less than 0.01). The specificity of exercise imaging (97 percent) electrocardiograms the sensitivity of exercise imaging was not significantly different from that of exercise electrocardiograms (80 versus 74 percent), but the sensitivity of both tests combined (92 percent) was higher than that of either test alone (p less than 0.01). The specificity of exercise imaging (97 percent) was higher than that of exercise electrocardiograms (86 percent, p less than 0.02). The specificity of both tests combined was not significantly different from that of exercise electrocardiograms alone. The sensitivity (79 percent) and specificity (95 percent) of exercise imaging were not significantly different in patients with inconclusive exercise electrocardiograms when compared with those in patients whose exercise electrocardiograms were conclusive. These data indicate that exercise imaging is sensitive and specific in diagnosing coronary artery disease in the presence of diagnostic as well as nondiagnostic exercise electrocardiograms and that propranolol therapy does not affect the results.
Authors:
A S Iskandrian; B L Segal
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  48     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / physiopathology,  radiography,  radionuclide imaging
Coronary Angiography
Coronary Disease / physiopathology,  radiography,  radionuclide imaging*
Coronary Vessels / physiopathology,  radionuclide imaging
Electrocardiography
Exercise Test*
Female
Heart / physiopathology,  radionuclide imaging
Humans
Male
Middle Aged
Physical Exertion*
Propranolol / therapeutic use
Radioisotopes / diagnostic use
Thallium / diagnostic use*
Chemical
Reg. No./Substance:
0/Radioisotopes; 525-66-6/Propranolol; 7440-28-0/Thallium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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