| Value of exercise testing in assessing clinical state and prognosis in hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 11209145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomeric contractile proteins. A majority of patients with HCM are limited in terms of functional capacity, and a minority of these patients die suddenly. The main aims of management are symptom alleviation and prevention of sudden cardiac death. In patients with HCM, cardiopulmonary exercise testing provides a much more accurate index of functional capacity than New York Heart Association classification status, and it is useful in assessing symptoms after various therapeutic strategies have been implemented. Exercise testing is also valuable in identifying patients with HCM who are at high risk of sudden cardiac death and is an integral part of the algorithm in risk stratification and delivery of prophylactic therapy. Also, cardiopulmonary exercise testing plays an important role in differentiating HCM from other conditions associated with left ventricular hypertrophy, such as physiologic athlete's heart. Therefore, during the last few years, cardiopulmonary exercise testing has provided insights into the diagnosis, determinants, and mechanisms of exercise limitation in HCM. This understanding aids physicians in targeting therapy and developing new treatment modalities. |
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Authors:
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S Sharma; S Firoozi; W J McKenna |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiology in review Volume: 9 ISSN: 1061-5377 ISO Abbreviation: Cardiol Rev Publication Date: 2001 Mar-Apr |
Date Detail:
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Created Date: 2001-03-16 Completed Date: 2001-05-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9304686 Medline TA: Cardiol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 70-6 Citation Subset: IM |
Affiliation:
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Department of Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiomyopathy, Hypertrophic
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diagnosis*,
physiopathology Death, Sudden, Cardiac / epidemiology Exercise Test* Exercise Tolerance Heart Function Tests Humans Oxygen Consumption Prognosis Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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