Document Detail


Value of exercise testing in assessing clinical state and prognosis in hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  11209145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomeric contractile proteins. A majority of patients with HCM are limited in terms of functional capacity, and a minority of these patients die suddenly. The main aims of management are symptom alleviation and prevention of sudden cardiac death. In patients with HCM, cardiopulmonary exercise testing provides a much more accurate index of functional capacity than New York Heart Association classification status, and it is useful in assessing symptoms after various therapeutic strategies have been implemented. Exercise testing is also valuable in identifying patients with HCM who are at high risk of sudden cardiac death and is an integral part of the algorithm in risk stratification and delivery of prophylactic therapy. Also, cardiopulmonary exercise testing plays an important role in differentiating HCM from other conditions associated with left ventricular hypertrophy, such as physiologic athlete's heart. Therefore, during the last few years, cardiopulmonary exercise testing has provided insights into the diagnosis, determinants, and mechanisms of exercise limitation in HCM. This understanding aids physicians in targeting therapy and developing new treatment modalities.
Authors:
S Sharma; S Firoozi; W J McKenna
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiology in review     Volume:  9     ISSN:  1061-5377     ISO Abbreviation:  Cardiol Rev     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-03-16     Completed Date:  2001-05-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-6     Citation Subset:  IM    
Affiliation:
Department of Cardiological Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.
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MeSH Terms
Descriptor/Qualifier:
Cardiomyopathy, Hypertrophic / diagnosis*,  physiopathology
Death, Sudden, Cardiac / epidemiology
Exercise Test*
Exercise Tolerance
Heart Function Tests
Humans
Oxygen Consumption
Prognosis
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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