Document Detail


Value of estrogen and progesterone receptors in the management of intraepithelial squamous lesions of low grade
MedLine Citation:
PMID:  11268728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to know the prognostic value of estrogen receptors and progesterone receptors positives (ER+, PR+) in the management of low grade squamous intraepithelial lesions [(LGSIL), human papillomavirus (HPV) and cervical intraepithelial neoplasia grade 1 (CIN 1) and menopausal status]. MATERIAL AND METHODS: From January 1995 to January of 1999, was studied in 144 women with abnormal citology to HPV and CIN grades 1, 2 or 3. Colposcopy was carried out and two biopsies were taken from the suspicious lesion, they were sent for histopathological study, and for ER/PR by the dextran-coated charcoal technique. In addition to the receptor status information, histological type of squamous intraepithelial lesions (SIL), and menopausal status were recorded and analyzed and were correlated later. RESULTS: In normal cervix, 89% and 60% of specimens were ER+, PR+ (+6 fmol/mg protein) There was significant difference in ER status between the normal cervix con HPV and CIN, (P < 0.003), but no with PR (P > 0.53). ER levels in premenopausal and postmenopausal patients there was no significant difference (P > 0.27) but PR levels there was significant difference (P < 0.04). ER/PR levels in HPV o CIN grade no correlated to the histologic grade and menopausal status (P > 0.35, > 0.97, respectively). CONCLUSION: The women with levels ER+ were significant higher in the normal cervix than SIL, ER+, PR+ levels no correlated to the prognostic value in the management of LGSIL and menopausal status.
Authors:
J L González Sánchez; J Chávez Brambila; A Maricela Román; R Infante Martínez; L E Salazar Esquivel
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Ginecología y obstetricia de México     Volume:  69     ISSN:  0300-9041     ISO Abbreviation:  Ginecol Obstet Mex     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-27     Completed Date:  2001-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376552     Medline TA:  Ginecol Obstet Mex     Country:  Mexico    
Other Details:
Languages:  spa     Pagination:  1-5     Citation Subset:  IM    
Affiliation:
Instituto Mexicano del Seguro Social, Hospital de Gineco-Obstetricia Luis Castelazo Ayala.
Vernacular Title:
Valor de los receptores a estrógeno y a progesterona en el manejo de las lesiones escamosas intraepiteliales de bajo grado.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cervical Intraepithelial Neoplasia / chemistry*,  pathology,  virology
Female
Humans
Menopause
Middle Aged
Neoplasm Staging
Papillomaviridae
Papillomavirus Infections / complications
Prognosis
Receptors, Estrogen / analysis*
Receptors, Progesterone / analysis*
Tumor Virus Infections / complications
Uterine Cervical Neoplasms / chemistry*,  pathology,  virology
Chemical
Reg. No./Substance:
0/Receptors, Estrogen; 0/Receptors, Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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