| Value of electropharmacologic testing in idiopathic dilated cardiomyopathy and sustained ventricular tachyarrhythmias. | |
| | |
MedLine Citation:
|
PMID: 3414554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Electrophysiologic studies in 64 patients with idiopathic dilated cardiomyopathy who had sustained ventricular tachycardia or ventricular fibrillation were performed. A sustained ventricular tachyarrhythmia was induced in 43 patients (67%). Electropharmacologic testing predicted an antiarrhythmic drug effective in 15 of 35 patients in whom sustained monomorphic ventricular tachycardia could be induced reproducibly (43% of tested patients, 23% of all patients). During median follow-up of 1.6 years, there were 32 arrhythmia recurrences and 24 cardiac arrests. Multivariate regression analysis identified treatment with a drug predicted to be effective at electropharmacologic testing as the only predictor of freedom from arrhythmia recurrence (p = 0.01); and treatment with a drug predicted to be effective at electropharmacologic testing and lower New York Heart Association functional class as independent predictors of freedom from cardiac arrest (p = 0.03 and p = 0.02, respectively). At median follow-up, the incidences of freedom from arrhythmia recurrence and from cardiac arrest were both 100% during treatment with a drug predicted to be effective at electropharmacologic testing versus 54 +/- 8% and 62 +/- 7%, respectively, during other treatments. These findings indicate that results of electropharmacologic testing accurately predict freedom from arrhythmia recurrence and cardiac arrest in patients with idiopathic dilated cardiomyopathy and sustained ventricular tachyarrhythmias. |
| | |
Authors:
|
L B Liem; C D Swerdlow |
Related Documents
:
|
1282254 - Postpausal ventricular fibrillation analyzed by holter-ecg: a case report. 3901344 - Preoperative assessment of high-risk surgical patients. 10488934 - Resuscitation in europe: a tale of five european regions. 12500734 - Rapid on-site defibrillation versus community program. 12796124 - Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected aga... 8808164 - Calcium antagonists during and after myocardial infarction. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of cardiology Volume: 62 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1988 Sep |
Date Detail:
|
Created Date: 1988-10-11 Completed Date: 1988-10-11 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 611-6 Citation Subset: AIM; IM |
Affiliation:
|
Cardiology Division, Stanford University Medical Center, California 94305. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Anti-Arrhythmia Agents / therapeutic use* Cardiac Pacing, Artificial Cardiomyopathy, Dilated / physiopathology* Electrocardiography Electrophysiology Female Follow-Up Studies Heart Arrest / diagnosis Humans Male Middle Aged Predictive Value of Tests Recurrence Tachycardia / drug therapy, physiopathology* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Arrhythmia Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Left ventricular response to submaximal and maximal exercise in asymptomatic aortic regurgitation.
Next Document: Cardiovascular response to exercise after the Mustard operation for simple and complex transposition...