Document Detail

Value of echocardiography for observing left ventricular hypertrophy in the diagnosis of myocardial microvascular damage in hypertensives.
MedLine Citation:
PMID:  12865226     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the value of the echocardiographic observation of the left ventricular hypertrophy (LVH) in diagnosing myocardial microvascular damage in patients with essential hypertension (EH). METHODS: After intravenous injection with Quanfuxian (a contrast agent consisting of albumin and C3F8 prepared by Nanfang Hospital), the values of A (the maximum number of microbubbles accumulating in the local tissues for assessing the density of local microvessels), beta (the filling velocity of contrast agent for evaluating local blood flow velocity) and A x beta (the product of A and beta for estimating local myocardial blood flow) at rest and after dipyridamole injection were measured by intermittent harmonic imaging with myocardial contrast echocardiography (MCE). The ratios of A and beta along with the microvascular coronary flow velocity reserve (CFVR) were also calculated. RESULTS: Compared with the control group, the rest values of A, beta and A.beta in EH patients were higher, especially in those with LVH. After dipyridamole injection, the values of A, beta, A x beta and the ratios of A and beta, along with CFVR as well, were significantly lowered (P <0.01), and the reductions were especially obvious in LVH cases. As the hypertension exacerbated, the values of A and A x beta tended to increase in positive correlation with systolic and diastolic blood pressure (P <0.01), while the ratio of A and CFVR were decreased, the latter was inversely correlated with diastolic blood pressure (r=-0.55, P <0.01). Positive correlations were noted of the values of A and A x beta with the left ventricular mass and left ventricular mass index (P <0.01). CONCLUSION: EH patients, especially those with LVH, are characterized by increased rest myocardial microvascular blood flow, impaired myocardial microvascular flow reserve and endothelium independent vasodilation relaxing ability, and reduced capillary density, and these conditions tend exacerbate as the disease worsens. Microvascular function impairment should be suspected when complication of LVH arises in the EH patients. As a new important noninvasive technique, MCE can be a promising modality for diagnosing microvascular disease in essential hypertension.
Dong-sheng Chi; Yi-li Liu; Peng Wang; Xiao-lin Chen; Jian Liu; Zhi-bin Xie; Qi Li; Wen-chao Ou; Jian-cheng Xiu; Dao-gang Zha; Ping-sheng Wu; Ding-li Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA     Volume:  23     ISSN:  1000-2588     ISO Abbreviation:  Di Yi Jun Yi Da Xue Xue Bao     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-16     Completed Date:  2004-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9426110     Medline TA:  Di Yi Jun Yi Da Xue Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  702-5     Citation Subset:  IM    
Department of Cardiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
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MeSH Terms
Coronary Circulation
Coronary Disease / ultrasonography*
Hypertension / complications,  physiopathology*
Hypertrophy, Left Ventricular / ultrasonography*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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