Document Detail

Value of echo-Doppler derived pulmonary vascular resistance, net-atrioventricular compliance and tricuspid annular velocity in determining exercise capacity in patients with mitral stenosis.
MedLine Citation:
PMID:  17965491     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The present study sought to determine if echo-Doppler-derived pulmonary vascular resistance (PVR echo), net-atrioventricular compliance (Cn) and tricuspid peak systolic annular velocity (Sa), as parameters of right ventricular function, have value in predicting exercise capacity in patients with mitral stenosis (MS). METHODS AND RESULTS: Thirty-two patients with moderate or severe MS without left ventricular systolic dysfunction were studied. After comprehensive echo-Doppler measurements, including PVR echo, tricuspid Sa and left-sided Cn, supine bicycle exercise echo and concomitant respiratory gas analysis were performed. Measurements during 5 cardiac cycles representing the mean heart rate were averaged. Increment of resting PVR(echo) (r=-0.416, p=0.018) and decrement of resting Sa (r=0.433, p=0.013) and Cn (r=0.469, p=0.007) were significantly associated with decrease in %VO(2) peak. The predictive accuracy for %VO2 peak could increase by combining these parameters as Sa/PVR echo (r=0.500, p=0.004) or Cn. (Sa/PVR echo) (r=0.572, p=0.001) independent of mitral valve area, mean diastolic pressure gradients or presence of atrial fibrillation. CONCLUSIONS: Measurement of PVR echo, Cn and Sa might provide important information about the exercise capacity of patients with MS.
Eui-Young Choi; Jaemin Shim; Sung-Ai Kim; Chi Young Shim; Se-Jung Yoon; Seok-Min Kang; Donghoon Choi; Jong-Won Ha; Se-Joong Rim; Yangsoo Jang; Namsik Chung
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2008-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1721-7     Citation Subset:  IM    
Cardiology Division, Yonsei Cardiovascular Center and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
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MeSH Terms
Atrioventricular Node / physiology*
Blood Flow Velocity / physiology
Echocardiography, Doppler
Exercise Test
Exercise Tolerance / physiology*
Heart Rate / physiology
Lung Compliance / physiology
Middle Aged
Mitral Valve Stenosis / physiopathology*
Tricuspid Valve / physiology*
Vascular Resistance / physiology*
Ventricular Function, Right / physiology*

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