Document Detail

Value of diagnostic radioiodine scintigraphy and thyroglobulin measurements after rhTSH injection.
MedLine Citation:
PMID:  19212608     Owner:  NLM     Status:  MEDLINE    
Measurements of thyroglobulin (Tg) levels 72 h after administration of recombinant human thyrotropin (rhTSH) are recommended by the manufacturer in the follow-up of patients with differentiated thyroid carcinoma (DTC). In our department, Tg measurements are performed both 24 h and 72 h after administration of rhTSH, together with 72 h post rhTSH 131I whole body scintigraphy (WBS). The OBJECTIVE of this study is to compare the diagnostic usefulness of Tg measurements 24 and 72 h after rhTSH administration, and 131I WBS. PATIENTS AND METHODS: 181 patients were included who had been referred to our Nuclear Medicine Department for follow-up after 131I ablation of DTC. Tg measurements 24 h (Tg24) and 72 h (Tg72) after rhTSH, and 131I WBS, were done in all patients. The lower detection limit of Tg was 0,2 microg/l. RESULTS: 47 patients (26%) had detectable Tg levels: in 4/47 cases (8%) only Tg24 was detectable (always <1 microg/l), and in 6/47 cases (11%), only Tg72 was detectable. In 10/47 patients with detectable Tg-levels, Tg24 and Tg72 tested equally. In 27/47 cases, Tg24 was lower, and in 10/47 higher, than Tg72. Two patients with one or two positive Tg-test results also had a positive 131I WBS. In 8 patients (14%) only the 131I WBS was positive; an anatomical substrate for such a Tg-negative positive WBS was confirmed in only 2 patients. CONCLUSION: Tg-measurement 72 hours after rhTSH injection reveals all clinically relevant detectable Tg-levels. Diagnostic 131I scintigraphy may be omitted, even in high-risk patients.
F A Verburg; B de Keizer; J M H de Klerk; E G W M Lentjes; C J M Lips; J W van Isselt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuklearmedizin. Nuclear medicine     Volume:  48     ISSN:  0029-5566     ISO Abbreviation:  Nuklearmedizin     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-12     Completed Date:  2009-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7609387     Medline TA:  Nuklearmedizin     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  26-9     Citation Subset:  IM    
University Medical Center Utrecht, Department of Nuclear Medicine, Utrecht, Netherlands.
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MeSH Terms
Carcinoma, Papillary / blood,  surgery
Iodine Radioisotopes / diagnostic use*
Recombinant Proteins / administration & dosage,  pharmacology*
Thyroglobulin / blood*
Thyroid Neoplasms / blood,  surgery
Thyrotropin / administration & dosage,  pharmacology*
Thyroxine / therapeutic use
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Recombinant Proteins; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin

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