| Value of diagnostic radioiodine scintigraphy and thyroglobulin measurements after rhTSH injection. | |
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MedLine Citation:
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PMID: 19212608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Measurements of thyroglobulin (Tg) levels 72 h after administration of recombinant human thyrotropin (rhTSH) are recommended by the manufacturer in the follow-up of patients with differentiated thyroid carcinoma (DTC). In our department, Tg measurements are performed both 24 h and 72 h after administration of rhTSH, together with 72 h post rhTSH 131I whole body scintigraphy (WBS). The OBJECTIVE of this study is to compare the diagnostic usefulness of Tg measurements 24 and 72 h after rhTSH administration, and 131I WBS. PATIENTS AND METHODS: 181 patients were included who had been referred to our Nuclear Medicine Department for follow-up after 131I ablation of DTC. Tg measurements 24 h (Tg24) and 72 h (Tg72) after rhTSH, and 131I WBS, were done in all patients. The lower detection limit of Tg was 0,2 microg/l. RESULTS: 47 patients (26%) had detectable Tg levels: in 4/47 cases (8%) only Tg24 was detectable (always <1 microg/l), and in 6/47 cases (11%), only Tg72 was detectable. In 10/47 patients with detectable Tg-levels, Tg24 and Tg72 tested equally. In 27/47 cases, Tg24 was lower, and in 10/47 higher, than Tg72. Two patients with one or two positive Tg-test results also had a positive 131I WBS. In 8 patients (14%) only the 131I WBS was positive; an anatomical substrate for such a Tg-negative positive WBS was confirmed in only 2 patients. CONCLUSION: Tg-measurement 72 hours after rhTSH injection reveals all clinically relevant detectable Tg-levels. Diagnostic 131I scintigraphy may be omitted, even in high-risk patients. |
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Authors:
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F A Verburg; B de Keizer; J M H de Klerk; E G W M Lentjes; C J M Lips; J W van Isselt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nuklearmedizin. Nuclear medicine Volume: 48 ISSN: 0029-5566 ISO Abbreviation: Nuklearmedizin Publication Date: 2009 |
Date Detail:
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Created Date: 2009-02-12 Completed Date: 2009-04-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7609387 Medline TA: Nuklearmedizin Country: Germany |
Other Details:
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Languages: eng Pagination: 26-9 Citation Subset: IM |
Affiliation:
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University Medical Center Utrecht, Department of Nuclear Medicine, Utrecht, Netherlands. Verburg_E@klinik.uni-wuerzburg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Papillary
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blood,
surgery Female Humans Iodine Radioisotopes / diagnostic use* Male Recombinant Proteins / administration & dosage, pharmacology* Thyroglobulin / blood* Thyroid Neoplasms / blood, surgery Thyrotropin / administration & dosage, pharmacology* Thyroxine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 0/Recombinant Proteins; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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