Document Detail


Value of the determination of TNF-alpha in the plasma of patients with non-Hodgkins lymphoma.
MedLine Citation:
PMID:  8833407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present report describes the value of the plasma determination of TNF-alpha, at diagnosis, in 43 patients with non-Hodgkin's lymphoma (NHL), related to their clinical presentation and the new International Prognosis Index (IPI). We also compare the levels of TNF-alpha with those of LDH, beta-2-microglobulin (beta-2-m), and ferritin. At diagnosis, the mean values of the quotients between the marker values and the maximum value of normal (ratio:r-) are placed 7 times higher than normal for r-TNF-alpha, whereas those of r-beta-2-m and r-LDH are 2,4 and 1,4 times more respectively. We found a relationship between the value of r-TNF-alpha and the ECOG, Ann Arbor stage, the number of affected extranodal sites, and between the values of r-beta-2-m with r-LDH. The best correlation was obtained between the values of r-TNF-alpha and r-beta-2-m and IPI, however r-TNF-alpha best stratify the four risk groups in this prognosis index.
Authors:
J Macia; X Gomez; A Esquerda; B Perez; V Callao; C Marzo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  20     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-06-12     Completed Date:  1997-06-12     Revised Date:  2006-04-24    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  481-6     Citation Subset:  IM    
Affiliation:
Hematology and Clinic Analysis Departments, Arnau de Vilanova University Hospital, Lleida, Spain.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cyclophosphamide / administration & dosage
Disease Progression
Doxorubicin / administration & dosage
Female
Humans
L-Lactate Dehydrogenase / blood
Lymphoma, Non-Hodgkin / blood*,  drug therapy,  pathology
Male
Neoplasm Proteins / blood*
Prednisone / administration & dosage
Prognosis
Severity of Illness Index
Tumor Markers, Biological / blood
Tumor Necrosis Factor-alpha / analysis*
Vincristine / administration & dosage
beta 2-Microglobulin / analysis
Chemical
Reg. No./Substance:
0/CHOP protocol; 0/Neoplasm Proteins; 0/Tumor Markers, Biological; 0/Tumor Necrosis Factor-alpha; 0/beta 2-Microglobulin; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine; EC 1.1.1.27/L-Lactate Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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