| Value of coronary stenotic flow velocity acceleration on the prediction of long-term improvement in functional status after angioplasty. | |
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MedLine Citation:
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PMID: 11431661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The coronary flow velocity acceleration at the stenotic site (SVA), defined as a > or = 50% increase in resting stenotic velocity when compared with the reference segment, has been shown to be highly sensitive and specific for the diagnosis of a hemodynamically significant stenosis. In this study, we describe the value of postprocedural SVA for the prediction of a lack of improvement in functional activity at long-term follow-up balloon angioplasty (BA). METHODS: We investigated the improvement in functional activity in patients undergoing single native vessel angioplasty and intracoronary Doppler (before BA, after BA, and again at 6-month follow-up) as part of the Doppler Endpoints Balloon Angioplasty Trial Europe (DEBATE) I trial. Lack of improvement was defined as no change in Duke Activity Status Index (DASI) at 6-month follow-up, whereas SVA was defined as > or = 50% elevation in resting velocity at the treated area compared with the distal measurement. RESULTS: SVA was found more frequently in patients without improvement in DASI (45% vs 31%, P =.03). Similar percent diameter stenosis and coronary flow velocity reserve were observed in patients with and those without improvement in DASI at follow-up. By multivariate regression analysis, the presence of SVA (P = .029; odds ratio, 1.97; 95% confidence interval, 1.07 to 3.63) and an elevated DASI at baseline (P < .001; odds ratio, 1.05; 95% confidence interval, 1.03 to 1.07) were associated with a lack of improvement at follow-up. CONCLUSIONS: The detection of SVA was associated with failure of improvement in functional activity at follow-up after coronary intervention. |
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Authors:
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M Albertal; E Regar; J J Piek; G Van Langenhove; S G Carlier; A Thury; G Sianos; E Boersma; B de Bruyne; C di Mario; P W Serruys; |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 142 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-06-29 Completed Date: 2001-08-09 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 81-6 Citation Subset: AIM; IM |
Affiliation:
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Thoraxcenter, Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon* Blood Flow Velocity Coronary Angiography Coronary Circulation / physiology* Coronary Disease / physiopathology*, therapy*, ultrasonography Echocardiography, Doppler Female Follow-Up Studies Humans Male Middle Aged Predictive Value of Tests Regression Analysis Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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