| Value of contrast-enhanced FDG PET/CT in detection and presurgical assessment of pancreatic cancer: a prospective study. | |
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MedLine Citation:
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PMID: 21155879 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and Aim: Positron Emission Tomography (PET) using (18) F-fluorodeoxyglucose (FDG) associated with Computed Tomography (CT) is increasingly used for the detection and the staging of pancreatic cancer, but data regarding its clinical added value in pre-surgical planning is still lacking. The aim of this study is to investigate the performance of FDG PET associated with contrast-enhanced CT in detection of pancreatic cancer. Methods: We prospectively evaluated FDG PET/CT studies obtained in patients with suspicion of operable pancreatic cancer between May 2006 and January 2008. Staging was conducted according to a standardized protocol, and findings were confirmed in all patients by surgical resection or biopsy examination. Results: Forty-five patients with a median age of 69 (range 22 - 82) were included in this study. Thirty-six had malignant tumors and nine had benign lesions (20%). The sensitivity of enhanced versus unenhanced PET/CT in the detection of pancreatic cancer was 96% vs. 72% (p = 0.076), the specificity 66.6% vs. 33.3% (p = 0.52), the positive predictive value 92.3% vs. 80% (p = 0.3), the negative predictive value 80% vs. 25% (p = 0.2), and the accuracy 90.3% vs. 64% (p = 0.085). Conclusions: Our preliminary data obtained in a limited number of patients shows that contrast-enhanced FDG PET/CT offers a good sensitivity in the detection and assessment of pancreatic cancer, but at the price of a relatively low specificity. Enhanced PET/CT seems to be superior to unenhanced PET/CT. Further larger prospective studies are needed to establish its value for pre-surgical diagnosis and staging in pancreatic cancer. |
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Authors:
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Nicolas C Buchs; Leo Bühler; Pascal Bucher; Jean-Pierre Willi; Jean-Louis Frossard; Arnaud D Roth; Pietro Addeo; Antoine Rosset; Sylvain Terraz; Christoph D Becker; Osman Ratib; Philippe Morel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-10-18 |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: - ISSN: 1440-1746 ISO Abbreviation: - Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Clinic for Visceral and Transplantation Surgery, Department of Surgery, University Hospitals of Geneva, Switzerland. Department of Nuclear Medicine, University Hospitals of Geneva, Switzerland. Division of Gastroenterology, Department of Internal Medicine, University Hospitals of Geneva, Switzerland. Oncosurgery Unit, Department of Internal Medicine, University Hospitals of Geneva, Switzerland. Department of Radiology, University Hospitals of Geneva, Switzerland. |
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