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Value of biomarker-based diagnostic test in differential diagnosis of hemorrhagic-ischemic stroke.
MedLine Citation:
PMID:  21744736     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND AND AIM: Stroke is an emergency which threatens life and the third leading cause of death in developed countries and the leading cause of long-term disability. By means of this study, it was aimed to evaluate the position of triage stroke panel in differential diagnosis of acute hemorrhagic stroke and ischemic stroke and sub-types of ischemic stroke.
MATERIAL AND METHODS: Patients with acute stroke admitted to Emergency Department were prospectively recruited between June 2008-January 2009. BNP, D-dimer, MMP-9, S-100b levels were asseyed. Statistical significance for intergroup differences was assessed by Pearson's chi2 for categorical variables and Mann-Whitney U test or Kruskal-Wallis test for continuous variables.
RESULTS AND CONCLUSION: A total of 100 consecutive patients with a diagnosis of stroke were evaluated. Of these, 29 (29%) patients had brain hemorrhages on the computed tomography scan performed the Emergency Department, 71 (71%) patients had ischemic stroke. It was observed that the intercept obtained as a result of jointly evaluating BNP, D-dimer, MMP9 and S100b is more important in differential diagnosis (p < 0.005). We suggest that using a combination of plasma biomarkers may be usefull to ischemic or hemorrhagic stroke for differential diagnosis (Tab. 4, Ref. 22).
Authors:
C Kavalci; H Genchallac; P Durukan; Y Cevik
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  112     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2011  
Date Detail:
Created Date:  2011-07-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  398-401     Citation Subset:  IM    
Affiliation:
Trakya University Faculty of Medicine, Emergency Department, Edirne, Turkey. cemkavalci@yahoo.com
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