Document Detail


Value of bile acid determination for the diagnosis of neonatal jaundice.
MedLine Citation:
PMID:  2102973     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum concentrations of bile acids and bilirubin, and activity of alanine transferase and alkaline phosphatase as well as bile acid and bilirubin levels in duodenal contents were determined in 90 infants aged 1-44 weeks (including 49 under 10 weeks of age) admitted to hospital for prolonged jaundice. Infants with extrahepatic cholestasis were found to have statistically higher serum bile acid and bilirubin concentrations. Oral administration of cholestyramine produced a statistically significant decrease in serum bile acids and bilirubin in infants with intrahepatic cholestasis under 10 weeks of age. In 24 out of the 30 infants with biliary tract obstruction total absence of bile acids in the duodenal contents was demonstrated while in the others the concentration did not exceed 0.2 mmol/l. The mean bile acid concentration in infants with intrahepatic cholestasis was 2.81 mmol/l while in 8 infants out of the 60 bile acids were either absent or present in trace amounts. The method had an 84.4% sensitivity.
Authors:
J Pawłowska; Z Bogoniowska; M Szczygielska-Kozak; Z Wróblewska; J Socha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Materia medica Polona. Polish journal of medicine and pharmacy     Volume:  22     ISSN:  0025-5246     ISO Abbreviation:  Mater Med Pol     Publication Date:    1990 Apr-Jun
Date Detail:
Created Date:  1991-09-27     Completed Date:  1991-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0236526     Medline TA:  Mater Med Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  112-7     Citation Subset:  IM    
Affiliation:
Child Health Center, Warszawa, Poland.
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MeSH Terms
Descriptor/Qualifier:
Bile Acids and Salts / blood*
Cholestasis, Extrahepatic / blood*,  diagnosis
Cholestasis, Intrahepatic / blood*,  diagnosis
Diagnosis, Differential
Female
Humans
Infant
Infant, Newborn / blood*
Male
Chemical
Reg. No./Substance:
0/Bile Acids and Salts

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