| Value of PAX8 and WT1 Immunostaining in Confirming the Ovarian Origin of Metastatic Carcinoma in Serous Effusion Specimens. | |
| | |
MedLine Citation:
|
PMID: 22261458 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
We evaluated the detection rates of PAX8 and WT1 immunostaining in 68 (45 as cell blocks, 23 as smears) serous effusion specimens that had a cytologic diagnosis of metastatic carcinoma of ovarian origin. Of the cases, 58 (85%) were positive for PAX8, 56 (82%) were positive for WT1, and 64 (94%) were immunoreactive with either or both markers. Detection rates of PAX8 and WT1 were 85% (44/52) and 92% (48/52), respectively, for metastatic serous carcinoma and 100% (5/5) and 20% (1/5), respectively, for metastatic clear cell carcinoma. Detection rates using cell blocks and smears were 91% and 78%, respectively, with PAX8 and 82% and 83%, respectively, with WT1. We concluded that PAX8 and WT1 had comparable overall detection rates in confirming ovarian origin of malignant effusion. The combination of both markers substantially improved the detection rate. Cell blocks and smears can be used for staining, but a cell block is preferred for PAX8 staining. |
| | |
Authors:
|
Lichao Zhao; Ming Guo; Nour Sneige; Yun Gong |
Related Documents
:
|
21858728 - Relationships of esr1 and xbp1 expression in human breast carcinoma and stromal cells i... 9663598 - Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childh... 21868188 - Therapeutic mammaplasties: full local control of breast cancer in one surgical stage wi... 8218878 - Family history of cancer and seizures in young children with brain tumors: a report fro... 22073218 - Glut 5 is not over-expressed in breast cancer cells and patient breast cancer tissues. 15622698 - Metastatic pleomorphic carcinoma of lung presenting as abdominal pain. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of clinical pathology Volume: 137 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 304-9 Citation Subset: AIM; IM |
Affiliation:
|
Dept of Pathology, Unit 53, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Interplay of Age Stratification and HPV Testing on the Predictive Value of ASC-US Cytology: Resu...
Next Document: 20q- clonality in a case of oral sweet syndrome and myelodysplasia.