Document Detail

Value of PAX2 Immunostaining in Tumor Diagnosis: A Review and Update.
MedLine Citation:
PMID:  23060065     Owner:  NLM     Status:  In-Data-Review    
PAX2 is a member of the PAX family of transcription factors that, together with PAX8, is involved in the regulation of the organogenesis of the kidney and the Müllerian system. Recent investigations have demonstrated that, among tumors, PAX2 is commonly expressed in epithelial tumors of the kidney and female genital tract. Although PAX2 expression has also been reported in B-cell lymphomas and rhabdomyosarcomas, especially alveolar rhabdomyosarcomas, it has been suggested that the positivity in these tumors was most probably due to a cross-reactivity of the anti-PAX2 antibody used in those investigations with other members of the PAX protein family. An analysis of published studies indicates that PAX2 sensitivity for epithelial renal neoplasms and epithelial tumors of the female genital tract is lower than that of PAX8. In contrast to the latter marker, however, PAX2 does not appear to be expressed in epithelial tumors of the thyroid gland or thymus. Because of its restricted expression, PAX2 has proved to be a useful immunohistochemical marker with a wide range of diagnostic applications in surgical pathology, some of which will be briefly reviewed.
Nelson G Ordóñez
Related Documents :
24124115 - Multiple tumor types including leiomyoma and wilms tumor in a patient with gorlin syndr...
23505735 - Primary ocular chondrosarcoma in a discus (symphisodon aequifasciatus).
24915895 - Invasion pattern and histologic features of tumor aggressiveness correlate with mmr pro...
24777305 - Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germi...
15705875 - Suppression of melanotroph carcinogenesis leads to accelerated progression of pituitary...
21548585 - Delivery of soluble vegf receptor 1 (sflt1) by gene electrotransfer as a new anti-angio...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in anatomic pathology     Volume:  19     ISSN:  1533-4031     ISO Abbreviation:  Adv Anat Pathol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435676     Medline TA:  Adv Anat Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  401-9     Citation Subset:  IM    
M.D. Anderson Cancer Center, University of Texas, Houston, TX.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Assessing physician competency: an update on the joint commission requirement for ongoing and focus...
Next Document:  Update in molecular diagnostics in melanocytic neoplasms.