| Value of PAX2 Immunostaining in Tumor Diagnosis: A Review and Update. | |
| | |
MedLine Citation:
|
PMID: 23060065 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
PAX2 is a member of the PAX family of transcription factors that, together with PAX8, is involved in the regulation of the organogenesis of the kidney and the Müllerian system. Recent investigations have demonstrated that, among tumors, PAX2 is commonly expressed in epithelial tumors of the kidney and female genital tract. Although PAX2 expression has also been reported in B-cell lymphomas and rhabdomyosarcomas, especially alveolar rhabdomyosarcomas, it has been suggested that the positivity in these tumors was most probably due to a cross-reactivity of the anti-PAX2 antibody used in those investigations with other members of the PAX protein family. An analysis of published studies indicates that PAX2 sensitivity for epithelial renal neoplasms and epithelial tumors of the female genital tract is lower than that of PAX8. In contrast to the latter marker, however, PAX2 does not appear to be expressed in epithelial tumors of the thyroid gland or thymus. Because of its restricted expression, PAX2 has proved to be a useful immunohistochemical marker with a wide range of diagnostic applications in surgical pathology, some of which will be briefly reviewed. |
| | |
Authors:
|
Nelson G Ordóñez |
Related Documents
:
|
7480155 - Photosensitization of murine tumor, vasculature and skin by 5-aminolevulinic acid-induc... 9097975 - Laser-photosensitizer assisted immunotherapy: a novel modality for cancer treatment. 23388175 - Primary signet-ring cell carcinoma of the urinary bladder successfully managed with cis... 22937785 - Rapidly involuting congenital hemangioma associated with profound, transient thrombocyt... 9232275 - Prognostic factors for metachronous contralateral breast cancer: a comparison of the li... 7932625 - An autoreactive t cell clone generated in the autologous mixed lymphocyte reaction in a... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Advances in anatomic pathology Volume: 19 ISSN: 1533-4031 ISO Abbreviation: Adv Anat Pathol Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9435676 Medline TA: Adv Anat Pathol Country: United States |
Other Details:
|
Languages: eng Pagination: 401-9 Citation Subset: IM |
Affiliation:
|
M.D. Anderson Cancer Center, University of Texas, Houston, TX. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessing physician competency: an update on the joint commission requirement for ongoing and focus...
Next Document: Update in molecular diagnostics in melanocytic neoplasms.