| Value of Magnetic Resonance and 18FDG PET-CT in Predicting Tumor Response and Resectability of Primary Locally Advanced Cervical Cancer After Treatment With Intensity-Modulated Arc Therapy: A Prospective Pathology-Matched Study. | |
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MedLine Citation:
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PMID: 22237382 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To report on the value of magnetic resonance imaging (MRI) and 2-deoxy-2-[18] fluoro-D-glucose positron emission tomography computed tomography (FDG PET-CT) in predicting resectability and pathological response of primary locally advanced cervical cancer after neoadjuvant intensity-modulated arc therapy (IMAT) with or without cisplatin (C). METHODS AND MATERIALS: Twenty-seven patients with International Federation of Gynecology and Obstetrics stages IB2 to IVA cervical cancer were treated with IMAT-C followed by extrafascial hysterectomy (EH). All patients received MRI and FDG PET-CT after IMAT-C. The end points of this study were to: RESULTS: An R0 resection was obtained in all patients. None of the EH specimens contained macroscopically visible tumor. In 13 patients, no viable tumor cells were found and only 14 had residual microscopic disease. Twenty-four of 27 MRIs were able to correctly predict R0 resection. A negative MRI was 100% predictive for the end point "R0 resection." The specificity and NPV of MRI (end point 2) were 74% and 100%, respectively. No sensitivity or PPV could be calculated. The sensitivity, specificity, PPV, and NPV of FDG PET-CT were 29%, 62%, 44%, and 44%, respectively (end point 3). CONCLUSIONS: A negative MRI after IMAT-C predicts 100% correctly for R0 resection. The role of FDG PET-CT in predicting viable tumor cells at EH specimen is at least debatable. |
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Authors:
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Katrien Vandecasteele; Louke Delrue; Bieke Lambert; Amin Makar; Kathleen Lambein; Hannelore Denys; Philippe Tummers; Rudy Van den Broecke; Geert Villeirs; Gert De Meerleer |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: - ISSN: 1525-1438 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of *Radiology Oncology, †Radiology, ‡Nuclear Medicine, §Gynaecology, ∥Pathology, and ¶Medical Oncology, Gent University Hospital, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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