| Value of FDG PET in the Evaluation of Therapy Response in Nerve Root Neurolymphomatosis. | |
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MedLine Citation:
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PMID: 21467863 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 45-year-old man with history of B-cell lymphoma and new back pain underwent PET/CT that showed tracer uptake in multiple lumbosacral nerve roots, concerning for neurolymphomatosis. Histology after lumbar puncture revealed lymphoma involvement in the central nervous system. After cycle 3 of chemotherapy (RICE), restaging PET/CT (2 months after initial PET/CT) showed resolution of all abnormalities including nerve root uptake. Maximum standardized uptake value was 2.4 (equivalent to background level; prechemotherapy max SUV was 7.2; both SUVs were measured after time of flight (TOF) reconstruction). A subsequent cerebrospinal fluid analysis was negative for malignant cells consistent with response to treatment. This case is of particular interest, because we can demonstrate the utility of PET/CT imaging in nerve root neurolymphomatosis and are able to evaluate the therapy response by comparing tracer uptake on pre- with postchemotherapy imaging. |
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Authors:
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Roland Talanow; Sankaran Shrikanthan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 389-91 Citation Subset: IM |
Affiliation:
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From the Department of Nuclear Medicine, Imaging Institute, The Cleveland Clinic, Cleveland, OH. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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