| Value of Dual-Time-Point FDG PET/CT for Mediastinal Nodal Staging in Non-Small-Cell Lung Cancer Patients With Lung Comorbidity. | |
| | |
MedLine Citation:
|
PMID: 21552018 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
PURPOSE: : To evaluate the efficacy of dual-time-point F-18 fluorodeoxyglucose positron emission tomography (FDG PET)/ computed tomography (CT) for mediastinal nodal staging in non-small-cell lung cancer patients with lung comorbidity. MATERIALS AND METHODS: : Fifty-three pathologically proven non-small-cell lung cancer patients with pulmonary comorbidity and 49 patients as controlled group without comorbidity were enrolled. PET/CT was performed at 1-hour (whole body) post-FDG injection and repeated 2 hours (thoracic) after injection. All patients received radical surgery with system mediastinal lymph node (LN) dissection. The results of LN detection by single-time-point and dual-time-point scan were compared with the histopathologic findings. RESULTS: : On a per-patient basis, in patients with pulmonary comorbidity, the sensitivity, specificity, accuracy, and positive predictive values (PPV), and negative predictive values of single-time-point scan were 87.5%, 59.5%, 67.9%, 48.3%, and 91.7%, respectively. Those values of dual-time-point scan were 93.8%, 67.6%, 75.5%, 55.6%, and 96.2%, respectively. In patients without comorbidity, dual-time-point scan was similar in those values to single-time-point. On a per-nodal station basis, the specificity, accuracy, and PPV of dual-time-point scan were better than those of single-time-point with statistically significant differences (P = 0.017, 0.002, and 0.027, respectively) in patients with pulmonary comorbidity, but the difference was not statistically significant in patients with no pulmonary comorbidity. CONCLUSIONS: : Dual-time-point FDG PET/CT is more effective for mediastinal nodal staging than single-time-point in patients with pulmonary comorbidity. Dual-time-point scan was useful for diagnosis of mediastinal LN metastases in reducing the false-positive results in all patients, but improved specificity, accuracy, and PPV only in patients with pulmonary comorbidity. |
| | |
Authors:
|
Man Hu; Anqin Han; Ligang Xing; Wenfeng Yang; Zheng Fu; Chengsuo Huang; Pinliang Zhang; Li Kong; Jinming Yu |
Related Documents
:
|
19902328 - Mr characterisation of dysplastic nodules and hepatocarcinoma in the cirrhotic liver wi... 8061428 - Solitary hepatic metastasis: comparison of dynamic contrast-enhanced ct and mr imaging ... 21190758 - Demyelination of superficial white matter in early alzheimer's disease: a magnetization... 21514978 - [utility of pet/ct for mediastinal staging of non-small cell lung cancer in stage iii (... 15569108 - Meta-analysis: the detection of pancreatic malignancy with positron emission tomography. 22548928 - Stroke: high-field magnetic resonance imaging. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 429-33 Citation Subset: IM |
Affiliation:
|
From the *Department of Radiation Oncology and Shandong Province Key Laboratory of Radiation Oncology, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan, People's Republic of China; †Department of Oncology, Shandong University, Jinan, People's Republic of China; Departments of ‡Thoracic Surgery and §Nuclear Medicine, Shandong Cancer Hospital, Jinan, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of Dual-Time-Point F-18 FDG PET/CT in the Assessment of Pleural Effusion in Patients With Non...
Next Document: Limited Predictive Value of Dual-Time-Point F-18 FDG PET/CT for Evaluation of Pathologic N1 Status i...