| Value of 1H-magnetic resonance spectroscopy chemical shift imaging for detection of anaplastic foci in diffusely infiltrating gliomas with non-significant contrast-enhancement. | |
| | |
MedLine Citation:
|
PMID: 20971752 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective In diffusely infiltrating gliomas (DIG), positron emission tomography (PET) imaging is a powerful method for detection of anaplastic foci. Recently, (1)H-magnetic resonance spectroscopy chemical shift imaging (CSI) using choline/creatine (Cho/Cr) or choline/N-acetylaspartate (Cho/NAA) ratios has emerged as a new non-invasive, widely available alternative. The authors therefore correlated CSI with (11)C-methionine (MET)-PET data in a series of DIG with non-significant contrast-enhancement (CE). Methods Thirty-two patients with DIG were examined with single-slice CSI on a 3 T MRI and MET-PET. Maximum pathological intratumoural ratios of CSI (=CSI(max)) and maximum tumour-to-normal-brain PET ratios (=PET(max); T/N ratio) were determined. Coregistration of MRI with CSI and PET was performed, and the topographic overlap of CSI(max) and PET(max) was analysed. Histological criteria of anaplasia as well as cell proliferation rate were assessed in tumour samples inside and outside CSI(max). Results CSI showed a pathological ratio in all patients, whereas PET demonstrated a pathological T/N ratio in 21/32 patients. Topographical correlation of CSI(max) and PET(max) revealed a ≥50% overlap in 18/21 and <50% overlap in 3/21 patients, respectively. Cho/Cr(max) and Cho/NAA(max) showed a ≥50% overlap in 24/32 and a <50% overlap in 8/32 patients. Cell proliferation rate was significantly higher inside than outside the CSI(max) (13.6% vs 6.9%, p<0.001). Conclusion The results indicate that CSI is a promising method for detection of anaplastic foci within DIG with non-significant CE. Intraoperative use of CSI by multimodal neuronavigation may increase the reliability of detection of malignant areas in glioma surgery and therefore optimise allocation of patients to adjuvant treatments. |
| | |
Authors:
|
Georg Widhalm; Martin Krssak; Georgi Minchev; Adelheid Wöhrer; Tatjana Traub-Weidinger; Thomas Czech; Susanne Asenbaum; Christine Marosi; Engelbert Knosp; Johannes A Hainfellner; Daniela Prayer; Stefan Wolfsberger |
Publication Detail:
|
Type: Journal Article Date: 2010-10-22 |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 82 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-04-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
|
Languages: eng Pagination: 512-20 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, Medical University Vienna, Waehringer Guertel 18-20, 1097 Vienna, Austria; stefan.wolfsberger@meduniwien.ac.at. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Safety of transcranial Doppler 'bubble study' for identification of right to left shunts: an interna...
Next Document: Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review.