| Value of (18F)-FDG positron emission tomography, computed tomography, and magnetic resonance imaging in diagnosing primary and recurrent ovarian carcinoma. | |
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MedLine Citation:
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PMID: 10823629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare prospectively the accuracy of whole-body positron emission tomography (PET), CT and MRI in diagnosing primary and recurrent ovarian cancer. Nineteen patients (age range 23-76 years) were recruited with suspicious ovarian lesions at presentation (n = 8) or follow-up for recurrence (n = 11). All patients were scheduled for laparotomy and histological confirmation. Whole-body PET with FDG, contrast-enhanced spiral CT of the abdomen, including the pelvis, and MRI of the entire abdomen were performed. Each imaging study was evaluated separately. Imaging findings were correlated with histopathological diagnosis. The sensitivity, specificity and accuracy for lesion characterization in patients with suspicious ovarian lesions (n = 7) were, respectively: 100, 67 and 86% for PET; 100, 67 and 86% for CT; and 100, 100 and 100% for MRI. For the diagnosis of recurrent disease (n = 10), PET had a sensitivity of 100%, specificity of 50% and accuracy of 90%. The PET technique was the only technique which correctly identified a single transverse colon metastasis. Results for CT were 40, 50 and 43%, and for MRI 86, 100 and 89%, respectively. No statistically significant difference was seen. Neither FDG PET nor CT nor MRI can replace surgery in the detection of microscopic peritoneal disease. No statistically significant difference was observed for the investigated imaging modalities with regard to lesion characterization or detection of recurrent disease; thus, the methods are permissible alternatives. The PET technique, however, has the drawback of less accurate spatial assignment of small lesions compared with CT and MRI. |
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Authors:
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R A Kubik-Huch; W Dörffler; G K von Schulthess; B Marincek; O R Köchli; B Seifert; U Haller; H C Steinert |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European radiology Volume: 10 ISSN: 0938-7994 ISO Abbreviation: Eur Radiol Publication Date: 2000 |
Date Detail:
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Created Date: 2000-08-08 Completed Date: 2000-08-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 761-7 Citation Subset: IM |
Affiliation:
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Department of Radiology, Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma / diagnosis*, secondary Colonic Neoplasms / diagnosis, secondary Contrast Media Female Fluorodeoxyglucose F18 / diagnostic use* Follow-Up Studies Humans Laparotomy Magnetic Resonance Imaging* Middle Aged Neoplasm Recurrence, Local / diagnosis* Ovarian Neoplasms / diagnosis* Peritoneal Neoplasms / diagnosis, secondary Prospective Studies Radiography, Abdominal Radiopharmaceuticals / diagnostic use* Sensitivity and Specificity Tomography, Emission-Computed* Tomography, X-Ray Computed* Whole-Body Counting* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
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