| Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer. | |
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MedLine Citation:
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PMID: 15232708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study is to evaluate the clinical significance of (124)I positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with (131)I whole-body scintigraphy (WBS), dedicated PET and CT alone. Twelve thyroid cancer patients were referred for diagnostic workup and entered complete clinical evaluation, including histology, cytology, thyroglobulin level, ultrasonography, fluorine-18 fluorodeoxyglucose (FDG)-PET, FDG-PET/CT and CT. Lesion-based evaluation showed a lesion delectability of 56, 87 and 100% for CT, (124)I-PET, and combined (124)I-PET/CT imaging, respectively. Lesion delectability of (131)I-WBS was 83%. We conclude that (124)I-PET/CT imaging is a promising technique to improve treatment planning in thyroid cancer. It is particularly valuable in patients suffering from advanced differentiated thyroid cancer prior to radio-iodine therapy and in patients with suspected recurrence and potential metastatic disease. |
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Authors:
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L S Freudenberg; G Antoch; W Jentzen; R Pink; J Knust; R Görges; S P Müller; A Bockisch; J F Debatin; W Brandau |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article Date: 2004-06-30 |
Journal Detail:
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Title: European radiology Volume: 14 ISSN: 0938-7994 ISO Abbreviation: Eur Radiol Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-25 Completed Date: 2005-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 2092-8 Citation Subset: IM |
Affiliation:
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Clinic and Policlinic for Nuclear Medicine, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany. l.freudenberg@t-online.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma / classification, diagnosis* Female Humans Iodine Radioisotopes / diagnostic use Lymph Nodes / ultrasonography Male Middle Aged Neoplasm Staging Positron-Emission Tomography / methods* Reproducibility of Results Thyroid Gland / radiography*, radionuclide imaging* Thyroid Neoplasms / classification, diagnosis* Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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