Document Detail

Valsartan use in pediatric hypertension.
MedLine Citation:
PMID:  21453020     Owner:  NLM     Status:  In-Data-Review    
Hypertension affects up to 5% of school-aged children and is defined by an average systolic or diastolic blood pressure greater than the 95th percentile for age, sex and height. In prepubertal children a secondary cause for hypertension including renal disease, coarctation of the aorta or endocrine disease should be excluded by appropriate evaluation. The incidence and prevalence of essential hypertension in adolescents has increased together with the increase in obesity and now accounts for at least 50% of hypertension in this age group. Many children with primary hypertension and most children with secondary causes for hypertension require drug therapy. There are numerous drug classes that are presently used to treat hypertensive pediatric patients, which include β-blockers, peripheral α-blockers, direct vasodilators, ACE inhibitors, calcium channel blockers, diuretics and ARBs. This article will review the pharmacology of the ARB valsartan with respect to its efficacy, tolerability and safe use in hypertensive pediatric patients.
Kevin Ec Meyers; Brittany Behar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Future cardiology     Volume:  7     ISSN:  1744-8298     ISO Abbreviation:  Future Cardiol     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239345     Medline TA:  Future Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  151-9     Citation Subset:  IM    
Division of Pediatric Nephrology, 2nd Floor Main Building, The Children's Hospital of Philadelphia, 34th Street & Civic Center Blvd, Philadelphia, PA 19104, USA.
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