Document Detail

Valsartan plus hydrochlorothiazide: a review of its use since its introduction.
MedLine Citation:
PMID:  21728903     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: This review focuses on the role of the fixed-dose combination (FDC) drug valsartan/hydrochlorothiazide (HCTZ) in the treatment of hypertension. Effective blood pressure control often is not achieved with monotherapy and, instead, requires combinations of drugs with different mechanisms of action to produce additive or synergistic effects.
AREAS COVERED: FDC valsartan/HCTZ enhances not only efficacy for blood pressure control but also provides beneficial effects on target organs beyond that expected from arterial pressure reduction alone. Data describe key clinical trial experiences with the FDC, with particular attention to efficacy and tolerability. Literature searches of these various topics were conducted in January 2011. There is evidence of potential benefits with this combination associated with left ventricular hypertrophy, left ventricular dysfunction and renal disease. The FDC is an effective treatment for patients with hypertension and is superior to monotherapy than either drug alone.
EXPERT OPINION: In addition to the benefits of each drug, valsartan/HCTZ's metabolic interactions reduce some of the negative effects of both compounds. With its increased simplicity, minimal side-effect profile and efficacy without a significant cost penalty, valsartan/HCTZ represents an excellent choice for antihypertensive therapy.
Jujhar Bains; William B Smith
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Publication Detail:
Type:  Comparative Study; Journal Article; Review     Date:  2011-07-06
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  12     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-18     Completed Date:  2011-11-28     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  1975-84     Citation Subset:  IM    
Department of Cardiology , University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA.
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / administration & dosage,  adverse effects,  economics,  therapeutic use*
Antihypertensive Agents / administration & dosage,  adverse effects,  economics,  therapeutic use*
Diuretics / administration & dosage,  adverse effects,  therapeutic use*
Drug Combinations
Drug Costs
Drug Synergism
Hydrochlorothiazide / administration & dosage,  adverse effects,  economics,  therapeutic use*
Hypertension / drug therapy*,  economics,  physiopathology
Hypertrophy, Left Ventricular / prevention & control
Renal Insufficiency / prevention & control
Tetrazoles / administration & dosage,  adverse effects,  economics,  therapeutic use*
Valine / administration & dosage,  adverse effects,  analogs & derivatives*,  economics,  therapeutic use
Ventricular Dysfunction, Left / prevention & control
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Diuretics; 0/Drug Combinations; 0/Tetrazoles; 137862-53-4/valsartan; 58-93-5/Hydrochlorothiazide; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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