| Valsartan and the kidney: review of preclinical and clinical data. | |
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MedLine Citation:
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PMID: 11446269 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In both diabetic and nondiabetic renal disease, reducing blood pressure with antihypertensive therapy has beneficial effects on renal function. The key role of the renin-angiotensin system in blood pressure and volume homeostasis has long been established, but its importance for the overall normal functioning of the kidney itself is also increasingly being recognized. Angiotensin-converting enzyme (ACE) inhibitors, widely and successfully used in the treatment of hypertension, may also provide renal protection independent of blood pressure reduction; however, their relatively nonspecific mode of action in blocking an early metabolic step entails major clinical disadvantages, such as accumulation of bradykinin and substance P, that may cause the characteristic ACE-inhibitor side effects of persistent dry cough and, more rarely, angioneurotic edema. Angiotensin II antagonists or receptor blockers, a new class of antihypertensive agent, selectively antagonize the AT1 receptor subtype and, because of greater specificity, do not give rise to the side effects associated with ACE inhibitors. More important, these new drugs may have mechanistic advantages over other antihypertensives, including ACE inhibitors. |
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Authors:
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L M Ruilope |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in therapy Volume: 18 ISSN: 0741-238X ISO Abbreviation: Adv Ther Publication Date: 2001 Mar-Apr |
Date Detail:
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Created Date: 2001-07-11 Completed Date: 2001-08-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8611864 Medline TA: Adv Ther Country: United States |
Other Details:
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Languages: eng Pagination: 57-66 Citation Subset: T |
Affiliation:
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Hospital 12 de Octubre, Nephrology Service, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology Animals Antihypertensive Agents / pharmacology*, therapeutic use Blood Pressure / drug effects Diabetic Nephropathies / drug therapy, physiopathology Humans Hypertension / drug therapy, physiopathology Kidney / drug effects*, physiology, physiopathology Kidney Diseases / drug therapy, physiopathology Receptors, Angiotensin / antagonists & inhibitors* Tetrazoles / pharmacology*, therapeutic use Valine / analogs & derivatives*, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Receptors, Angiotensin; 0/Tetrazoles; 137862-53-4/valsartan; 7004-03-7/Valine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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