Document Detail


Valsartan-Induced Angioedema in a Patient on Angiotensin-Converting Enzyme Inhibitor for Years: Case Report and Literature Review.
MedLine Citation:
PMID:  20838200     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Angioedema is a rare but life-threatening adverse effect of administration of angiotensin-converting enzyme inhibitors (ACEIs) administration. It has been classically associated with ACEIs, although angioedema has also been reported with angiotensin receptor blockers (ARBs). Angioedema is a deep swelling of tissues just below the skin and mucous membranes, characterized by non-pitting asymmetric swelling that is usually non-pruritic. ARBs may cause an increase in plasma angiotensin II levels, which may lead to a negative feedback inhibition of ACE activity, predisposing to angioedema development. We report a case of valsartan-induced angioedema that occurred in a patient who was on ACEIs for years, with no incidence of angioedema.
Authors:
Ankur Kalra; Christine Cooley; Chandrasekar Palaniswamy; Ankit Kalra; Sergio L Zanotti-Cavazonni
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-9-10
Journal Detail:
Title:  American journal of therapeutics     Volume:  -     ISSN:  1536-3686     ISO Abbreviation:  -     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-9-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Division of Internal Medicine, Department of Medicine, Cooper University Hospital, UMDNJ-Robert Wood Johnson Medical School, Camden, NJ; 2Department of Medicine, New York Medical College, Valhalla, NY; 3Department of Medicine, Kalra Hospital and SRCNC, New Delhi, India; and 4Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, UMDNJ-Robert Wood Johnson Medical School, Camden, NJ.
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