Document Detail


Valsartan-induced angioedema in a patient on Angiotensin-converting enzyme inhibitor for years: case report and literature review.
MedLine Citation:
PMID:  20838200     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Angioedema is a rare but life-threatening adverse effect of administration of angiotensin-converting enzyme inhibitors (ACEIs) administration. It has been classically associated with ACEIs, although angioedema has also been reported with angiotensin receptor blockers (ARBs). Angioedema is a deep swelling of tissues just below the skin and mucous membranes, characterized by non-pitting asymmetric swelling that is usually non-pruritic. ARBs may cause an increase in plasma angiotensin II levels, which may lead to a negative feedback inhibition of ACE activity, predisposing to angioedema development. We report a case of valsartan-induced angioedema that occurred in a patient who was on ACEIs for years, with no incidence of angioedema.
Authors:
Ankur Kalra; Christine Cooley; Chandrasekar Palaniswamy; Ankit Kalra; Sergio L Zanotti-Cavazzoni
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of therapeutics     Volume:  19     ISSN:  1536-3686     ISO Abbreviation:  Am J Ther     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e189-92     Citation Subset:  IM    
Affiliation:
1Division of Internal Medicine, Department of Medicine, Cooper University Hospital, UMDNJ-Robert Wood Johnson Medical School, Camden, NJ 2Department of Medicine, New York Medical College, Valhalla, NY 3Department of Medicine, Kalra Hospital and SRCNC, New Delhi, India 4Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, UMDNJ-Robert Wood Johnson Medical School, Camden, NJ.
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