| Valproyl CoA: an active metabolite of valproate? | |
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MedLine Citation:
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PMID: 2156136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Valproic acid exhibits a time course of antiepileptic effects suggesting a major role for active metabolites. It is proposed that valproyl-CoA, a valproate metabolite previously identified in liver, may accumulate in brain as a result of normal fatty acid turnover processes. Valproyl CoA could contribute to valproate's antiepileptic activity by stimulating Na+, K+-ATPase activity when brain ATP concentration is low. |
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Authors:
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P Friel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Medical hypotheses Volume: 31 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-04-25 Completed Date: 1990-04-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 31-2 Citation Subset: IM |
Affiliation:
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Epilepsy Center, Harborview Medical Center, Seattle, WA 98104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyl Coenzyme A
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metabolism* Adenosine Triphosphate / metabolism Animals Anticonvulsants / metabolism Brain / metabolism Humans Models, Biological Sodium-Potassium-Exchanging ATPase / metabolism Valproic Acid / blood, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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NS 17111/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acyl Coenzyme A; 0/Anticonvulsants; 0/valproyl-coenzyme A; 56-65-5/Adenosine Triphosphate; 99-66-1/Valproic Acid; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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