Document Detail

Valproyl CoA: an active metabolite of valproate?
MedLine Citation:
PMID:  2156136     Owner:  NLM     Status:  MEDLINE    
Valproic acid exhibits a time course of antiepileptic effects suggesting a major role for active metabolites. It is proposed that valproyl-CoA, a valproate metabolite previously identified in liver, may accumulate in brain as a result of normal fatty acid turnover processes. Valproyl CoA could contribute to valproate's antiepileptic activity by stimulating Na+, K+-ATPase activity when brain ATP concentration is low.
P Friel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical hypotheses     Volume:  31     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-04-25     Completed Date:  1990-04-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-2     Citation Subset:  IM    
Epilepsy Center, Harborview Medical Center, Seattle, WA 98104.
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MeSH Terms
Acyl Coenzyme A / metabolism*
Adenosine Triphosphate / metabolism
Anticonvulsants / metabolism
Brain / metabolism
Models, Biological
Sodium-Potassium-Exchanging ATPase / metabolism
Valproic Acid / blood,  metabolism*
Grant Support
Reg. No./Substance:
0/Acyl Coenzyme A; 0/Anticonvulsants; 0/valproyl-coenzyme A; 56-65-5/Adenosine Triphosphate; 99-66-1/Valproic Acid; EC ATPase

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