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Valproic acid and phenobarbital blood levels during the first month of treatment with the ketogenic diet.
MedLine Citation:
PMID:  21108622     Owner:  NLM     Status:  Publisher    
Coppola G, Verrotti A, D'Aniello A, Arcieri S, Operto FF, Della Corte R, Ammendola E, Pascotto A. Valproic acid and phenobarbital blood levels during the first month of treatment with the ketogenic diet.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2010.001359.x.© 2010 John Wiley & Sons A/S. Objective -  The aim of this study was to assess how the ketogenic diet influences the blood levels of antiepileptic drugs in the first month of treatment in a pediatric population with drug-resistant epilepsy. Methods -  The plasma concentrations of antiepileptic drugs were investigated in an open study on 36 consecutive children and adolescents (20 males), aged between 6 months and 16 years (mean age 4.7 years), who were put on the ketogenic diet because of medically refractory epilepsy. The plasma levels of antiepileptic drugs were determined 30 days and immediately before the diet and on days 8, 15, 22 and 29 after the start of the diet. The daily dose of each drug was not changed during the first month of treatment, while the daily dose of benzodiazepines was reduced by up to 30% if excessive sedation or drowsiness occurred. Results -  While plasma concentrations of phenobarbital did not change in the first month on the ketogenic diet (mean increase of 2.3 mg/l ± 1.0), valproic acid showed a slight but not significant decrease (mean decresase of 6.7 mg/l ± 3.2), 2 weeks after the start of the diet. Conclusions -  Adjustments in the daily dose of either drug before the start of the diet do not however appear to be justified.
G Coppola; A Verrotti; A D'Aniello; S Arcieri; F F Operto; R Della Corte; E Ammendola; A Pascotto
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-5-17
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  -     ISSN:  1600-0404     ISO Abbreviation:  -     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-11-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Clinic of Child and Adolescent Neuropsychiatry, Second University of Naples, Naples, Italy Department of Pediatrics, Section of Pediatrics, University of Chieti, Chieti, Italy Department of Pediatrics, Federico II University, Naples, Italy.
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