| Valproic acid, a molecular lead to multiple regulatory pathways. | |
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MedLine Citation:
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PMID: 17448293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Valproic acid (2-propyl pentanoic acid) is a drug used for the treatment of epilepsy and bipolar disorder. Although very rare, side effects such as spina bifida and other defects of neural tube closure indicate that valproic acid interferes with developmental regulatory pathways. Recently obtained data show that valproic acid affects cell growth, differentiation, apoptosis and immunogenicity of cultured cancer cells and tumours. Focused studies uncovered the potential of valproic acid to interfere with multiple regulatory mechanisms including histone deacetylases, GSK3 alpha and beta, Akt, the ERK pathway, the phosphoinositol pathway, the tricarboxylic acid cycle, GABA, and the OXPHOS system. Valproic acid is emerging as a potential anticancer drug and may also serve as a molecular lead that can help design drugs with more specific and more potent effects on the one side and drugs with wide additive but weaker effects on the other. Valproic acid is thus a powerful molecular tool for better understanding and therapeutic targeting of pathways that regulate the behaviour of cancer cells. |
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Authors:
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M Kostrouchová; Z Kostrouch; M Kostrouchová |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Folia biologica Volume: 53 ISSN: 0015-5500 ISO Abbreviation: Folia Biol. (Praha) Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-23 Completed Date: 2007-05-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0234640 Medline TA: Folia Biol (Praha) Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 37-49 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Pathology, Institute of Inherited Metabolic Disorders of the 1st Faculty of Medicine, Charles University, Prague, Czech Republic. marta.kostrouchova@lfl.cuni.cz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / administration & dosage, pharmacology*, therapeutic use Antineoplastic Combined Chemotherapy Protocols / therapeutic use Gene Expression Regulation, Neoplastic / drug effects Humans Neoplasms / drug therapy, genetics Teratogens / toxicity Valproic Acid / analogs & derivatives, chemistry, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Teratogens; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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