Document Detail


Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality.
MedLine Citation:
PMID:  12504768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A baby born to an epileptic mother had dysmorphological features associated with 47,XXX karyotype. The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy. Dysmorphological features detected in baby were intrauterine growth retardation, hypertelorism, flattened nasal bridge, low set malformed auriculas, micrognathia, very small an bow-shaped mouth with thin upper lip, cleft palate, arachnodactyly, camptodactyly, secundum atrial septal defect, bilateral hammer toes and decreased creases on the soles. At 6 months old she showed motor retardation. The molecular analysis of parents revealed that extra X chromosome was inherited from the mother. In this case whether the dysmorphological features and 47,XXX karyotype were caused by lamotrigine and valproic acid treatment during pregnancy or coincidence is in question.
Authors:
Ferda Ozkinay; Ozgur Cogulu; Cumhur Gunduz; Deniz Yilmaz; Nilgun Kultursay
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  534     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-30     Completed Date:  2003-03-14     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  197-9     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Faculty of Medicine, Ege University, Izmir, Turkey. egetam@med.ege.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / genetics
Abnormalities, Multiple / chemically induced*,  genetics
Adult
Anticonvulsants / adverse effects
Chromosome Aberrations / chemically induced*
Chromosomes, Human, X / drug effects*
Cleft Palate / chemically induced,  genetics
Epilepsy / drug therapy*
Female
Fetal Growth Retardation / chemically induced,  genetics
Humans
Infant
Infant, Newborn
Karyotyping
Pedigree
Pregnancy
Pregnancy Complications / drug therapy*
Prenatal Exposure Delayed Effects*
Triazines / adverse effects*
Valproic Acid / adverse effects*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Triazines; 99-66-1/Valproic Acid; U3H27498KS/lamotrigine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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