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Valproic acid-induced abnormal behavior.
MedLine Citation:
PMID:  20174523     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
A 12-year-old female was admitted to hospital with complaints of abnormal behavior. She was on valproic acid 200mg twice daily and clobazam 5mg at night for the past 13 weeks for her complex partial seizures with secondary generalized seizures. On day 60 of the treatment with valproic acid she developed behavioral disturbances and initiated treatment with tablet chlorpromazine, olanzapine and risperidone. During the present hospitalization, as there was no improvement in abnormal behavior, antipsychotics were discontinued and she was on observation for five days. On day 6, valproic acid was replaced with carbamazepine. Patient started recovering gradually from the abnormal behavior three days after the withdrawal of valproic acid and completely recovered after three months. Causality of valproic acid-induced abnormal behavior was 'possible'. Behavioral disturbances associated with valproic acid are rare and is reversible upon discontinuation of the drug. There is a need for vigilance on abnormal behavioral effects in patients receiving valproic acid.
Authors:
Nanjangud Chandrashekar Nagalakshmi; Madhan Ramesh; Gurumurthy Parthasarathi; Anand Harugeri; Mary Sam Christy; Belur Seshachala Keshava
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of psychiatry     Volume:  52     ISSN:  1998-3794     ISO Abbreviation:  Indian J Psychiatry     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0013255     Medline TA:  Indian J Psychiatry     Country:  India    
Other Details:
Languages:  eng     Pagination:  71-3     Citation Subset:  -    
Affiliation:
Department of Pharmacy Practice, J.S.S. College of Pharmacy, Mysore, India.
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